Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Red Alder has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Alnus bark is astringent precisely because of its condensed tannin content, and condensed tannins bind non-haem iron in the intestinal lumen and reduce its uptake from the same meal. This is the same interaction documented for strong tea and for other high-tannin botanicals. Anyone taking an alder bark preparation and an iron supplement should separate them by a couple of hours. The interaction belongs to the tannin fraction, not to any alder-specific compound.
Condensed tannins bind protein through hydrogen bonding and hydrophobic interaction, which is literally the chemistry that turns hide into leather and the reason astringent botanicals dry the mouth. Given with a protein supplement, tannin-rich bark forms complexes in the gut lumen. Whether this meaningfully reduces amino acid availability at ordinary bark-tea amounts has not been quantified. Flagging it is more useful than ignoring it.
Ascorbate reduces ferric to ferrous iron and forms a soluble chelate that resists tannin binding, which is why vitamin C is the standard counter to polyphenol inhibition of non-haem iron. In a meal containing a tannin-rich bark preparation, adding ascorbate partly offsets the effect. This does not fully cancel a heavy tannin load. It is a mitigation, not an erasure.
Red alder bark contains oregonin, a diarylheptanoid structurally related to the curcuminoid family and the compound most cited in Alnus rubra phytochemistry. Diarylheptanoids as a class have been examined for redox and phase II handling in laboratory systems. Silymarin is a conventional companion in that context. Both sides of this pairing rest on in vitro chemistry, and no human work supports it.
Nothing specific on file for Red Alder. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.