S. boulardii CNCM I-745
One of the few supplements that actually delivers. Proven to support diarrhea with real clinical backing.
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Verdict
9/10 Strong
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Evidence
Grade B / 100+ Studies
Norans Kepals, Independent Researcher & Supplement Expert
March 1, 2026
The No-BS Summary
8 things. 60 seconds. Everything you need.
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WHAT IT DOES
Probiotic yeast. Antibiotic-resistant gut support.
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DOES IT WORK?
This one actually works. The most-studied S. boulardii strain. Clinical trials support its use for C. diff, AAD, and acute diarrhea. This specific strain has the deepest evidence base.
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HOW MUCH TO TAKE
See product label
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COST
Mid-range. $35-50/month. Standard for most people.
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FIRST 24 HOURS
Don't expect miracles on day one. It's building in your system.
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AFTER A FEW WEEKS
Give it 4-8 weeks for full effects. Patience pays.
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SAFETY
Safe for most people. No red flags at normal doses.
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HOW IT FEELS
Take during antibiotics. Prevents the runs. Gut stays stable.
2The Breakdown
Quick Answers
Dose-Response Curve
How effective is s. boulardii cncm i-745 at different doses? Here's what the research shows.
Effectiveness %
0
25
50
75
100
MIN 1000000.0g
SWEET SPOT 10000000.0g
PLATEAU 50000000.0g
Dose (CFU)
0-14%
Sub-therapeutic
<1000000.0g
14-80%
Effective
1000000.0g-10000000.0g
~80%
Optimal
10000000.0g
80%
Diminishing
>50000000.0g
Moderate confidenceBased on clinical data + estimates
Source: ISAPP consensus statement 2019 + Ford 2014 meta-analysisBottom line: Most research uses 10000000.0g daily. Below 1000000.0g, you're probably wasting money. Above 50000000.0g, you're not getting extra benefit.
Dosing Guide
When
As directed
How
See product label
Food
With or without food
Onset & Feel
WEEKS
Effects build over time
Take during antibiotics. Prevents the runs. Gut stays stable.
Cycle
As needed
How to Take It
S. boulardii CNCM I-745 comes in several formats. Pick what fits your lifestyle.
Capsules/Tablets
Pre-measured doses, easy to take.
✓ Convenient✓ No taste✓ Portable✗ More expensive✗ May need multiple
Powder
Mix with water or a shake.
✓ Cheapest✓ Flexible dosing✗ Needs mixing✗ Taste varies
Softgels
Oil-based for fat-soluble nutrients.
✓ Better absorption for fats✓ No taste✗ Larger pills
Pick this:
Capsules for convenience, powder for value.
Skip this:
Check for unnecessary fillers and additives.
Delivery affects convenience and cost, not usually effectiveness.
Did you know?
Many studies and counting.
3Deep Dive
The Science, Simplified
For those who want the full picture
Based on 50 human trials.
Scientific Consensus
65/10
Trust Signals
Grade B
Evidence
50+
Studies
30
Human Trials
0
Meta-analyses
👍 Strong evidence. Most claims hold up under scrutiny.
Mechanism of Action
Mechanism under research.
Research Summary
Scientific consensus: 65/10. Based on 50 human trials.
Consensus: 65/10STRONG Evidence
Origins & Manufacturing
Where does s. boulardii cncm i-745 come from? Let's get nerdy.
How It's Made
Manufacturing process varies by supplier.
What to Look For
✓ Third-party tested✓ GMP certified
Drug & Supplement Interactions
4For You
Is S. boulardii CNCM I-745 right for YOU?
Get a personalized verdict based on your health profile.
Products with S. boulardii CNCM I-745
Supplements that contain this ingredient
Medical Disclaimer
This content is for informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any supplement regimen, especially if you have medical conditions or take medications. IngredientMD does not endorse any specific products.