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Iron + Herbs
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Iron + Herbs.

Strong for its nicheFloradix, verified Oct 2026Formula verified. Independently reviewed.Independent review. Not commissioned by Floradix.

Vitamin B12 is the lead active here, studied most for vitamin B12 status. Thiamin is the most studied active here, with 11 human studies behind it, each one cited. Who it fits: skews toward women, adults.

Clinically dosedFull label disclosure
13Active ingredients46Human studies6.8 mcgVitamin B12
Iron + HerbsVerified by IngredientMD
FloradixIngredientMD
The verdict
Strong for its niche
For Skews toward women, adults.
How we verify

The brand submits the formula. We read the supplement facts panel and weigh dose, form and synergy against the clinical evidence. Labs test. IngredientMD verifies. The fee pays for review time, never for the outcome.

The formula
Thiamin: Filling everyday nutrient gapsExtensively studied
Riboflavin: Filling everyday nutrient gapsExtensively studied
Vitamin B6: Filling everyday nutrient gapsWell studied
Vitamin B12: Vitamin B12 statusKey driver
Iron: Filling everyday nutrient gapsWell studied
Proprietary Blend: A 5.9 g blend of seven ingredients, listed by weight.Supporting role
Aqueous herbal extract from carrot root: Filling everyday nutrient gaps. In the 5.9 g Proprietary Blend with six others, listed first.Supporting role
Stinging nettle leaf / dwarf nettle leaf: Filling everyday nutrient gaps. In the 5.9 g Proprietary Blend with six others, listed second.Supporting role
Spinach leaf: Methylation. In the 5.9 g Proprietary Blend with six others, listed third.Supporting role
Couch grass root: Kidney and urinary tract support. In the 5.9 g Proprietary Blend with six others, listed fourth.Supporting role
Fennel fruit: Comfort after a heavy meal. In the 5.9 g Proprietary Blend with six others, listed fifth.Supporting role
Kelp: Iodine status. In the 5.9 g Proprietary Blend with six others, listed sixth.Well studied
Hibiscus flower: Oxidative stress defence. In the 5.9 g Proprietary Blend with six others, listed seventh.Well studied

How we read this product

Source: Supplement facts
Supplement Facts panel for Iron + Herbs
  1. 01
    We read the label.

    The panel on the left is the one we evaluated, line by line.

  2. 02
    Every active, separately.

    All 13 actives checked against the clinical evidence: dose, form, and what the research actually shows.

  3. 03
    Then the formula as a whole.

    Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong for its niche".

  4. 04
    Earned, not bought.

    The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.

Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.

The receipts

46
Human studies
6.8 mcg
Vitamin B12
2.3 mg
Thiamin
3.6 mg
Riboflavin
2 mg per serving sits inside the studied 1 mg-50 mg range
Thiamin, NIH ODS + Lonsdale 2006 review
4 mg per serving sits inside the studied 1 mg-25 mg range
Riboflavin, NIH ODS + Schoenen 1998

Cross-checked against 878 documented interactions for these actives.

Read the evidenceThiamin, the evidence →Riboflavin, the evidence →Vitamin B6, the evidence →Vitamin B12, the evidence →Iron, the evidence →Aqueous herbal extract from carrot root, the evidence →

Inside the formula

Thiamin
11 studies
Filling everyday nutrient gaps
Extensively studied
Riboflavin
Filling everyday nutrient gaps
Extensively studied
Vitamin B6
Filling everyday nutrient gaps
Well studied
Vitamin B12
Vitamin B12 status
Key driver
Iron
Filling everyday nutrient gaps
Well studied
Proprietary Blend
A 5.9 g blend of seven ingredients, listed by weight.
Supporting role
Aqueous herbal extract from carrot root
Filling everyday nutrient gaps. In the 5.9 g Proprietary Blend with six others, listed first.
Supporting role
Stinging nettle leaf / dwarf nettle leaf
Filling everyday nutrient gaps. In the 5.9 g Proprietary Blend with six others, listed second.
Supporting role
Spinach leaf
Methylation. In the 5.9 g Proprietary Blend with six others, listed third.
Supporting role
Couch grass root
Kidney and urinary tract support. In the 5.9 g Proprietary Blend with six others, listed fourth.
Supporting role
Fennel fruit
Comfort after a heavy meal. In the 5.9 g Proprietary Blend with six others, listed fifth.
Supporting role
Kelp
Iodine status. In the 5.9 g Proprietary Blend with six others, listed sixth.
Well studied
Hibiscus flower
Oxidative stress defence. In the 5.9 g Proprietary Blend with six others, listed seventh.
Well studied
In context

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

The people it speaks toFieldwork 2019

12.3% of US adults

met the fruit intake recommendation and 10.0% the vegetable recommendation in 2019, in the Behavioral Risk Factor Surveillance System across 49 states.

CDC, MMWR, 2022
This formulaNHANES 2017-2018, published 2021

57.6%

During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.

CDC National Center for Health Statistics
42 more
The people it speaks to

60.2% of US adults aged 20 and over

took a dietary supplement in the past 30 days, and 38.7% took two or more, in the 2021 to 2023 National Health and Nutrition Examination Survey.

CDC National Center for Health Statistics, 2026
Daily use

59 to 66 days

was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.

Systematic review and meta-analysis, 2024
Hibiscus flower

Meta-analysis, 2022

Pooling controlled trials, hibiscus sabdariffa intake lowered systolic and diastolic blood pressure readings compared with control in adults.

Nutrition reviews
Kelp

Meta-analysis, 2023

Pooled trials found brown seaweed supplementation linked to small reductions in total and LDL cholesterol in the adults studied.

Marine drugs
Hibiscus flower

Meta-analysis, 2020

Across pooled trials in adults, hibiscus (roselle) supplementation shifted blood lipid readings in a favourable direction versus control.

Phytotherapy Research
Hibiscus flower

Randomised trial, 2025

An 8-week shot combining standardised hibiscus with inulin lowered lipid and glucose readings in adults carrying excess body weight, so the effect belongs to the combination rather than hibiscus alone.

Nutrients
Riboflavin

Randomised trial, 2013

In adults with elevated blood pressure carrying the MTHFR 677TT genotype, riboflavin 1.6 mg per day lowered systolic blood pressure by about 5.6 mmHg versus placebo over 16 weeks.

The paper
Wilson et al., 2013PMID 23608654
Thiamin

Cohort study, 2026

Reports an association between dietary thiamin, riboflavin and niacin intake and elevated blood pressure and pulse pressure. An association in intake data, not a demonstration of cause.

Medicine
Hibiscus flower

Randomised trial, 2021

A trial tested hibiscus combined with lemon verbena extract, so the reported effects belong to the combination and not to hibiscus alone.

Molecules
Aqueous herbal extract from carrot root

Systematic review, 2024

Across the reviewed human studies, higher dietary carotenoid intake tracked with more favourable cardiovascular risk markers, an association rather than a demonstrated cause.

Nutrients
Hibiscus flower

Randomised trial, 2022

A polyphenol-rich roselle jelly drink improved blood lipid, antioxidant and inflammatory marker readings relative to placebo over the supplementation period. These are markers, not outcomes.

Oxidative Medicine and Cellular Longevity
Spinach leaf

Randomised trial, 2021

Over twelve weeks a spinach extract was associated with greater improvement in skeletal muscle strength and fitness measures than placebo in adults older than 50. These are performance measures in a single trial.

Nutrients
Spinach leaf

Meta-analysis, 2026

Pooling trials of dietary nitrate, the source of nitrate in leafy greens such as spinach, the review examined effects on body weight measures in adults.

Frontiers in public health
Hibiscus flower

Randomised trial, 2022

A polyphenolic extract of Lippia citriodora and Hibiscus sabdariffa was assessed for appetite regulation measures in adults with excess body weight. The intervention was the combined extract.

European Journal of Nutrition
Aqueous herbal extract from carrot root

Randomised trial, 2024

Daily supplementation with carrot-derived rhamnogalacturonan-I altered gut microbiota composition in healthy adults. Composition is a measured community change, not a clinical outcome.

Biomedicine and Pharmacotherapy
Kelp

Randomised trial, 2021

Daily intake of Laminaria japonica in Japanese adults was followed by changes in body composition, serum lipid measures and thyroid hormone markers reported by the authors as modest.

Marine Drugs
Spinach leaf

Systematic review, 2025

Across observational studies, higher leafy vegetable intake was associated with a lower rate of developing clustered metabolic risk markers, an association rather than a demonstrated cause.

European journal of nutrition
Vitamin B6

Randomised trial, 2021

Pyridoxine hydrochloride supplementation was assessed against control for effects on circulating leptin and adiponectin, glycaemic indices and body measurements. The endpoints reported are biochemical and anthropometric markers, not clinical outcomes.

Clinical Nutrition Research
Spinach leaf

Randomised trial, 2015

An acute dose of a thylakoid-rich spinach extract was associated with changes in subjective satiety measures compared with control in a crossover design. Satiety ratings are self-reported markers, not intake or body-composition outcomes.

Journal of the American College of Nutrition
Kelp

Cohort study, 2026

An analysis using computer modeling found seaweed intake strongly linked to adult iodine levels, an association rather than a proven effect.

BMC Public Health
Riboflavin

Systematic review, 2026

The review found that reported responsiveness to riboflavin across inherited disorders of metabolism is uneven and rests largely on small series, so the strength of evidence varies by the specific condition.

Journal of Inherited Metabolic Disease
Vitamin B12

Systematic review, 2025

Reviews reported immune-cell and immune-marker changes alongside vitamin B12 repletion in adults whose B12 absorption is impaired. The outcomes summarised are markers, and the review names cyanocobalamin among the preparations used rather than isolating it.

Oxidative Medicine and Cellular Longevity
Fennel fruit

Meta-analysis, 2020

Pooling seven trials in 502 women, fennel eased period cramp pain about as well as the usual pain medicines, and beat placebo across another 468 women, though the placebo comparison varied enormously between studies.

Nutrients
Fennel fruit

Meta-analysis, 2021

Across two trials in 145 women at midlife, fennel improved a standard hormonal symptom score compared with placebo, while other studies found no clear effect on sexual function, quality of life or mood.

Complementary Therapies in Clinical Practice
Riboflavin

Meta-analysis, 2024

In a dose-response meta-analysis of randomised trials, riboflavin was associated with about 1.3 fewer severe recurring headache attacks per month compared with control.

Neurological Sciences
Kelp

Randomised trial, 2003

In adults with normal thyroid function, kelp supplementation raised blood thyroid-stimulating hormone, with a larger rise at the higher kelp dose, a marker rather than an outcome.

Endocrine practice
Thiamin

Randomised trial, 2019

Thiamin supplementation did not improve left ventricular ejection fraction in the participants studied. This is a failure to detect a difference in an imaging marker, not evidence that no difference exists.

The American Journal of Clinical Nutrition
Kelp

Meta-analysis, 2023

Pooling macro-algae supplementation trials, blood sugar and body measurement indices shifted only slightly, and several pooled comparisons showed no detectable difference from control.

The paper
Rezaei et al., 2023PMID 37469128
Vitamin B12

Open-label trial, 2024

A study measured how oral vitamin B12 absorption changes with dose in healthy adults, explaining why higher oral doses work once the usual route saturates.

Nutrients
Vitamin B6

Narrative review, 2025

A review collected reported allergic reactions to B vitamins, including pyridoxine used in combination products, mostly from injected forms, and case reports alone cannot show how common this is.

Life
Vitamin B12

Open-label trial, 2022

After cyanocobalamin supplementation the authors detected no association between serum vitamin B12 and the nocturnal sleep parameters measured. This is a failure to detect a relationship, not a demonstration that none exists.

Heliyon
Riboflavin

Meta-analysis, 2025

A nutrition-status analysis in children included thiamin among the micronutrients measured, reporting intake and status data rather than a result of giving supplements.

Journal of Human Nutrition and Dietetics
Thiamin

Randomised trial, 2026

Thiamin supplementation improved the thiamin pyrophosphate effect, a blood marker of thiamin adequacy, in children whose levels were low.

Scientific reports
Riboflavin

Meta-analysis, 2021

Pooling nine controlled trials in 673 people, vitamin B2 at 400 mg per day for three months lowered the frequency, days, duration and pain score of severe recurring headache attacks.

Nutritional Neuroscience

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

What this formula earned

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

  • Studied in people11 human studies on Thiamin back this formula, each one cited.
  • A mechanism that is settledHow Thiamin and Riboflavin work is settled pharmacology.
  • Recent work on the recordThe most recent study on this record was published in 2016.
  • Why this formatIt is a liquid, so the serving can be adjusted and it suits anyone who would rather not swallow a capsule.
  • The exact form, describedThe label names its forms exactly: Thiamin hydrochloride, Riboflavin, vitamin B2, Pyridoxine hydrochloride. The record says what each one is and what it suits.
  • A declared blend totalProprietary Blend declares its total, 5.9 g per serving, with 7 ingredients listed by weight.
  • Where it comes from and how it is madeThiamin is made by synthetic.
  • Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
  • A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
What the trials show

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

  • Thiaminabout 18 to 30 days of restricted intakeBuilds with daily use

    In the controlled depletion study the EFSA reference opinion reviews, restricting thiamin intake to 0.009 to 0.015 mg/MJ for 30 days brought urinary free thiamin excretion from a mean of 0.283 mg/24 h down to undetectable levels by day 18 of the depletion period.

    Promising
  • Thiaminabout 1 week of renewed intakeBuilds with daily use

    In the same depletion and repletion record the EFSA reference opinion reviews, erythrocyte transketolase activity fell progressively to about 75% of baseline during the 30-day depletion period and returned to its baseline value after 1 week of thiamin repletion.

    Promising

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

General timing

How each ingredient usually behaves over time.

12 ingredients, from each one's own page.

6 more

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

Chemical form

The same ingredient, carried differently.

What each form is, and where it fits in a formula. Measured findings carry the study that reported them.

  • Thiamin hydrochloride

    The chloride salt of the thiamin cation, highly water-soluble and hygroscopic.

    Fits
    Liquids, effervescents and any format where fast dissolution matters.
    Trade-off
    It draws moisture from the air, which complicates tabletting and dry blending, and it degrades faster as pH rises.
  • Riboflavin 5'-phosphate (sodium)

    Riboflavin with a phosphate group esterified onto the ribitol chain and supplied as its sodium salt. Chemically it is flavin mononucleotide (FMN), the same phosphorylated form the body itself makes from riboflavin.

    Fits
    The phosphate group and sodium counterion make it far more water soluble than the free vitamin, so it dissolves readily and suits liquids, effervescents, gummies, sublingual formats and drink mixes. It is the form many B-complex products list as the phosphorylated or activated B2.
    Trade-off
  • Pyridoxine hydrochloride

    Crystalline acid addition salt, freely water soluble, stable in dry form and to heat under acid conditions, and sensitive to light and alkaline pH

    Fits
    Tablets, capsules, liquids and fortified foods, and any process with a heat step, which is why it dominates the pharmacopoeial supply
    Trade-off
    It is a provitamer that requires two enzymatic steps, one of them riboflavin dependent, to reach the coenzyme form, and it carries a chloride counter-ion that dilutes the vitamer weight per gram
  • Cyanocobalamin

    A corrinoid with a cyanide group occupying the upper axial position on the cobalt atom, added during purification to give a single crystalline species.

    Fits
    Oral tablets, sublingual lozenges, gummies, fortified foods and injectable solutions, because the cyano ligand gives the molecule stability to light and heat during processing and storage.
    Trade-off
    The cyano ligand has to be removed and the cobalt reduced before the molecule can act as a cofactor, and that ligand is cleared renally.

Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.

Format

Liquid

It is a liquid, so the serving can be adjusted and it suits anyone who would rather not swallow a capsule.

Best forChildren, precise or scaled dosing, and anyone who cannot take solids.

Questions shoppers ask

Is Iron + Herbs independently verified?
Yes. IngredientMD reviewed this formula independently and verified it in Oct 2026. The verdict is earned, not bought: brands can't edit or purchase it.
What's in Iron + Herbs?
Iron + Herbs is built on Thiamin, Riboflavin, Vitamin B6, Vitamin B12, Iron, Proprietary Blend, and more. Each ingredient links to its own evidence page on IngredientMD.
Were ingredient interactions checked?
Yes. The combination was screened against 878 documented interactions for these actives in IngredientMD's interaction database.
Who is IngredientMD?
IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.

Independent review by IngredientMD, not commissioned by FloradixWork at Floradix? This verification is yours to claim →