Liquid Nighttime Multimineral.

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

• Studied in people22 human studies on Zinc back this formula, each one cited.
• A mechanism that is settledHow Vitamin C and Vitamin D3 work is settled pharmacology.
• Studied together, not just separatelyVitamin C and Calcium have been studied together, not only separately.
• Recent work on the recordThe most recent study on this record was published in 2026.
• Serving amount inside the studied rangeEach serving carries 8 mg of Zinc, inside the range the published research used.
• A stated daily maintenance amountZinc is here at a daily maintenance amount, which is what a daily supplement is for.
• Why this formatIt is a liquid, so the serving can be adjusted and it suits anyone who would rather not swallow a capsule.
• The exact form, describedThe label names its forms exactly: Ascorbic acid, Vitamin D3 in a carrier oil, lanolin-derived, Calcium carbonate. The record says what each one is and what it suits.
• A declared blend totalProprietary Blend declares its total, 67 mg per serving, with 4 ingredients listed by weight.
• Where it comes from and how it is madeVitamin C is made by fermentation.
• Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
• A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
• Interaction screen on the recordEvery active on this label was screened against the interaction record, and the screen is published with it.

The combinations the trials actually measured.

Two pairings in this formula have been studied as combinations in human trials. Each finding below is what a named study measured, cited and dated, never written by the brand.

• Zinc + SeleniumImmune

  In a two-year trial in older adults, zinc taken together with selenium improved the antibody response to influenza vaccination.

  Girodon et al., 1999 (Arch Intern Med)PMID 10218756

  Early
• Calcium + MagnesiumStrength

  In a 12-month randomised, double-blind trial, 98 adults aged 50 and over drank a litre a day of either a naturally calcium- and magnesium-rich mineral water or a low-mineral water. The mineral-rich group had fewer falls at the 6-month assessment and higher appendicular muscle mass, with the minerals delivered as drinking water rather than a capsule.

  Moretti et al., 2026 (Nutrients)PMID 41683292

  Promising

Findings from trials that studied these actives as a combination. Context for how the actives were tested together, not a statement about any individual and not a claim about this product.

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

• Vitamin Cwithin 24 hours of a single doseMeasured within a day

  In a randomised crossover trial, 12 healthy adults consumed 101.7 mg of vitamin C as a powder, as raw fruits and vegetables, or as juice, and plasma vitamin C rose after every intake form, with plasma and urinary levels tracked over the 24 hours following the single dose.

  Choi et al., 2025 (Nutrients)PMID 41228404

  Strong
• Vitamin D3about 3 months of daily useBuilds with daily use

  In the trial record, blood vitamin D rises for about 3 months of daily vitamin D3 and then holds at a plateau, near 69 nmol/L at 1,000 IU a day, from a starting level near 41 nmol/L.

  Vieth et al., 2001 (Am J Clin Nutr)PMID 11157326

  Early
• Calciumwithin about one to six hours of a single doseMeasured within a day

  A randomised cross-over trial in ten women of mean age 69 gave a single 500 mg dose of calcium as citrate fasting, citrate with a meal, fortified juice or a dairy product meal, with blood drawn before and at 1, 2, 4 and 6 hours. Serum ionised and total calcium increased significantly from baseline over six hours, with the rise similar after fortified juice, delayed when citrate was taken with a meal and smaller after the dairy meal. A separate double-blind cross-over trial in 25 postmenopausal women measured parathyroid hormone and a bone resorption marker 12 hours after a single calcium dose. Ten participants is a small sample, and what moved was blood chemistry, not a sensation.

  Bristow et al., 2015 (Br J Nutr)PMID 25851635

  Thomas et al., 2008 (Calcif Tissue Int)PMID 18553042

  Promising
• Zincover about five days of lozenges started within 24 hours of symptom onsetBuilds with daily use

  Across three randomised placebo-controlled trials pooled as individual patient data (199 adults with naturally acquired colds, 80 to 92 mg of elemental zinc a day as acetate lozenges), 70 percent of the zinc group had recovered by day 5 against 27 percent on placebo, and colds ran 2.73 days shorter against a 7 day average duration. A separate meta-analysis of seven lozenge trials (575 participants, doses above 75 mg a day, zinc acetate or zinc gluconate) measured cold duration 33 percent shorter, with no significant difference between the two salts.

  Hemilä et al., 2017 (Open Forum Infect Dis)PMID 28480298

  Hemilä et al., 2016 (Br J Clin Pharmacol)PMID 27378206

  Hemilä, 2017 (JRSM Open)PMID 28515951

  Strong
• Zincabout two to four weeks of daily intakeBuilds with daily use

  In a controlled feeding study in nine healthy men, six weeks of restricted zinc intake raised DNA strand breaks in peripheral blood cells, and four weeks of repletion at 11 mg a day, with 20 mg of supplemental zinc for the first seven days, reversed the rise. In a separate randomised placebo-controlled trial in 40 Ethiopian women eating a high-phytate diet, 20 mg a day of zinc sulfate for 17 days lowered mean comet tail moment from 39.7 to 30.0 while plasma zinc did not change significantly. Both windows were measured on a DNA damage marker in blood cells, not on a symptom.

  Song and colleagues 2009, American Journal of Clinical NutritionPMID 19515738

  Joray and colleagues 2015, Nutrition ResearchPMID 25491347

  Early
• Seleniumabout ten weeks of daily useBuilds with daily use

  In a 12 week randomised double-blind placebo-controlled trial in 119 healthy UK adults aged 50 to 64, mean plasma selenium rose from 95.7 ng/mL at baseline to steady state by week 10, reaching 118.3, 152.0 and 177.4 ng/mL on 50, 100 and 200 micrograms a day of selenium-enriched yeast. Plasma selenoprotein P rose in every selenium arm. Platelet glutathione peroxidase activity did not change significantly at any dose or form.

  Hurst and colleagues 2010, American Journal of Clinical NutritionPMID 20181815

  Promising

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

How each ingredient usually behaves over time.

12 ingredients, from each one's own page.

• Vitamin CWithin hours

  Blood levels rise within hours and tissue pools fill over days. Collagen-linked changes in skin and gums build over weeks and show as tissue quality, not as a sensation.

  Its own page, the plain answer on timing ↗

• Vitamin D3About six to twelve weeks

  25-hydroxyvitamin D climbs over roughly six to twelve weeks of daily dosing before it plateaus. It's a blood level you watch rather than a feeling.

  Its own page, the plain answer on timing ↗

• Calcium

  No acute sensation. Parathyroid hormone responds within hours, while bone density shifts over a year or more of steady intake, so this reads on a panel and a scan.

  Its own page, the plain answer on timing ↗

• Magnesium

  A looser stool can turn up the same day at the higher end. Sleep and cramp changes usually settle in across two to four weeks, because it is refilling a body-wide store.

  Its own page, the plain answer on timing ↗

• ZincWithin days

  Blood zinc moves within days. The parts you would notice, skin behaviour and immune resilience, take four to twelve weeks of steady daily intake.

  Its own page, the plain answer on timing ↗

• Selenium

  No felt onset. Plasma selenium and glutathione peroxidase activity rise over three to six weeks of daily intake and then plateau once the enzyme pool is filled.

  Its own page, the plain answer on timing ↗

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

The same ingredient, carried differently.

What each form is, and where it fits in a formula. Measured findings carry the study that reported them.

• Cholecalciferol (vitamin D3)

  The animal-sourced form of vitamin D, made in skin under UVB light and produced commercially from lanolin. Fat-soluble, so it travels with dietary fat and is stored in body fat.

  Fits

  Raising and holding vitamin D status, and the form most supplement trials use.

  Trade-off

  Being fat-soluble it accumulates with sustained high dosing, so intakes are set against the tolerable upper level rather than topped up freely.

  In a 12-week double-blind randomised controlled trial in 108 young women in urban Bangalore, most of whom began vitamin D-deficient, daily vitamin D3 at 400, 600 or 800 IU in a fortified wafer raised serum 25-hydroxyvitamin D, parathyroid hormone fell over time, and effects on bone-turnover markers were modest and not dose specific. The 800 IU dose brought 65 percent of participants to sufficiency.

  Peris et al., 2026 (Nutrients)PMID 42124077
• Silica (silicon dioxide)Active and formulation aid

  Silicon dioxide (SiO2), silicon bound to oxygen in a polymerized network. Supplied as amorphous or colloidal silica powder. The same compound appears at low levels as a flow and anti-caking agent.

  Fits

  A dry, stable powder that carries a high proportion of elemental silicon per gram and also serves as a flow agent, so it suits capsules, tablets and powder blends.

  Trade-off

  The silicon sits inside a polymerized particulate network rather than as free single-molecule silicic acid, and when it is used only as an excipient the amount present is usually tiny.

  In a crossover absorption study of fasting healthy adults measuring urinary silicon recovery against an orthosilicic acid positive control, colloidal silica recovery was about 1% of the ingested silicon dose (small subgroup, n=3).

  Sripanyakorn et al., 2009 (Br J Nutr)
• Hesperidin

  Hesperetin-7-O-rutinoside, a flavanone glycoside with very low water solubility.

  Fits

  Standard citrus bioflavonoid products and blends where the traditional isolated compound is wanted.

  Trade-off

  Poorly soluble and dependent on colonic bacteria for release, so exposure varies between people and appears late after dosing.

• Boron citrate

  Boric acid reacted with citric acid to give a soluble organic-acid complex that dissociates in gastric acid into boric acid and citrate.

  Fits

  Capsules, tablets and water-dispersible powders where a readily soluble mineral complex is wanted.

  Trade-off

  Elemental boron is a small fraction of the compound weight, so compound milligrams and boron milligrams must be stated separately. The citrate contributes a small acid-anion load.

Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.

Liquid

It is a liquid, so the serving can be adjusted and it suits anyone who would rather not swallow a capsule.