Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Broomrape has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Orobanchaceae species carry phenylethanoid glycosides such as acteoside, whose catechol group is oxidised to a quinone when it donates electrons. Ascorbate reduces that quinone back to the active phenol, which is the same recycling relationship it has with tocopherol. This is solution and cell-level chemistry, not a demonstrated effect in people.
Phenylethanoid glycosides are large, polar molecules that are absorbed poorly in their intact form. Gut bacteria hydrolyse the sugar and the ester bonds, releasing hydroxytyrosol and caffeic acid, which are absorbed far better than the parent. Circulating exposure therefore depends more on a person's gut flora than on the amount in the capsule.
Both materials deliver catechol-bearing phenolics that are conjugated by the same UGT, SULT and COMT enzymes in gut wall and liver. Taken together they compete for that conjugating capacity, which can raise free levels of whichever is present in smaller amount. The interaction is documented for phenolics as a class rather than for this plant specifically.
Catechol-containing phenolics bind ferric iron tightly and form coloured complexes that the gut does not absorb. Any phenolic-rich botanical taken in the same window as an iron supplement reduces the fraction of that iron taken up. Separating them by a couple of hours is the practical answer.
Rosmarinic acid and the phenylethanoid glycosides of Orobanchaceae are both built on caffeic acid ester chemistry and behave similarly as radical scavengers in laboratory assays. Combining them adds phenolic load without introducing a new mechanism. Read it as chemistry rather than as clinical synergy.
Polyphenols bind divalent minerals including zinc in the gut lumen, though less avidly than they bind iron. The effect is real for phenolic-dense extracts and negligible for small culinary amounts. Dose and timing decide whether it matters.
Nothing specific on file for Broomrape. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.