Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Motherwort Leaf has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Both plants are mint-family nervines with a documented history in the same formulas. Their calming effects add rather than cancel, which is the intent in an evening tea and a nuisance during the day. Neither the magnitude nor the duration of the combined effect has been quantified.
Valerian acts on GABAergic signalling and motherwort leaf leans calming through a less defined route. Combined, drowsiness stacks. Count anything else sedating, including antihistamines and alcohol, in the same total.
Chamomile apigenin binds benzodiazepine sites in preclinical work, and motherwort leaf adds its own calming reputation. In a blended tea the effect on alertness is additive. Note that chamomile is Asteraceae and carries its own cross-reactivity considerations for people sensitive to that family.
Tannin-rich leaf infusions form poorly absorbed complexes with non-heme iron, a well characterised effect in tea. Motherwort leaf carries a comparable tannin fraction. Taking an iron supplement with the infusion delivers less absorbed iron, so separate them by around two hours.
Bitter constituents on the tongue trigger a reflex increase in gastric secretion, while betaine hydrochloride adds acid directly. Together the gastric acid load is higher than with either alone. That is the intent in some digestive formulas and a problem for anyone with reflux.
Leonurine reduces platelet aggregation in laboratory systems and nattokinase acts on fibrin. Stacking them is a theoretical bleeding concern, particularly for anyone already on anticoagulant medication. The motherwort side of this is preclinical only.
Magnesium has a small measured effect on blood pressure and motherwort preparations have shown mild pressure-lowering signals in animals. The direction of both is the same, so effects add. Relevant mostly for people already taking pressure-lowering medication.
Glycyrrhizin from licorice raises blood pressure and lowers potassium through mineralocorticoid-like action, while motherwort leans the other direction. In a shared formula these work against each other on the same endpoint. This is a reason to look at the whole formula rather than each herb alone.
In Chinese practice motherwort leaf is yi mu cao and appears alongside dang gui in gynaecological formulas. Both are excluded during pregnancy in that same tradition. The pairing rests on documented practice, not on trials.
Nothing specific on file for Motherwort Leaf. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.