MassZymes.

28% of US adults

aged 18 and over say that digestive issues impact the quality of their life, a share that rises to about a third among those aged 18 to 44, per a 2023 Ipsos poll conducted for MDVIP.

32% of US adults

say they actively try to consume probiotics, and among them 60% try to do so at least once a day, per a 2022 IFIC survey on gut health.

59 to 66 days

was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.

61% to 74%

About 61 to 74 percent of adults refilling a long-term medicine on their own stopped within a year, versus 33 to 44 percent on one set pickup day.

Controlled trial, 2004

Men taking a multi-enzyme blend containing papain around a 30-minute downhill run recovered knee strength better and rated soreness lower than placebo, an effect from the blend, not papain alone.

Controlled clinical trial, 1989

In 10 adults with poor lactose digestion, a lactase tablet gave average breath hydrogen of 29 parts per million versus 33 for plain milk, a smaller drop than other methods.

Randomised trial, 2023

In a double blind trial, adults with recurring fullness and upper abdominal discomfort after meals reported greater symptom relief on a digestive enzyme blend than on placebo.

Randomised trial, 2013

Adults with long-standing digestive complaints who took 20 ml of papaya daily for 40 days reported less constipation and bloating than placebo, but the effect faded once stopped.

Meta-analysis, 2019

Across six trials after wisdom tooth removal, bromelain reduced pain in the first 24 hours and improved sleep and appearance, with no detectable effect on swelling or jaw opening.

Randomised trial, 1985

In adults who malabsorb lactose, adding 2 g of one lactase to milk cut breath hydrogen down near the level of pre-split milk, while another lactase source worked less well.

Randomised trial, 1996

In 10 adults, adding microbial phytase from Aspergillus niger to a wheat bran meal raised iron absorption from 14.3 percent to 26.1 percent, while native wheat phytase made no difference.

Systematic review, 2013

In human iron and zinc studies, phytase from Aspergillus niger raised iron and zinc absorption from phytate-rich foods, with 20 to 320 units per 100 g flour enough to help.

Randomised trial, 2007

In 8 healthy volunteers eating a bean-rich test meal, 1200 GalU of the enzyme reduced breath hydrogen and the severity of flatulence, and both tested doses lowered the total symptom score.

Meta-analysis, 2023

Across a review of 54 clinical reports with 39 pooled, oral bromelain lowered pain scores slightly more than control, by about 0.27 points on the pain scale, and topical bromelain shortened time to complete wound debridement by about 6.9 days.

Randomised trial, 1993

In adults who digest lactose poorly, microbial lactase preparations taken with milk containing 20 g of lactose cut peak and total breath hydrogen and made bloating and cramping milder, while with a 50 g lactose load the same 3,000 to 6,000 IU doses gave only a modest reduction the study could not distinguish from no change.

Systematic review, 2024

Reviewing the human and mechanistic evidence, bromelain's most consistently reported effects were on swelling, post-surgical recovery and markers of inflammation.

Randomised trial, 2024

A pineapple extract and bromelain preparation taken after lower wisdom tooth removal reduced swelling and reported pain compared with the control regimen.

Randomised trial, 2014

In young adults eating zinc-fortified maize porridge, phytase added just before eating or used to break down phytate during preparation raised fractional zinc absorption by more than 80 percent either way.

Randomised trial, 2026

Oral multienzyme supplementation was reported to alter postprandial plasma nutrient concentrations after a mixed meal in healthy adults. Amylase is one enzyme within the blend, and plasma nutrient concentrations are markers rather than clinical outcomes.

Systematic review, 2023

Across seven randomised trials using roughly 100 to 1200 mg a day for one to 16 weeks, the effect of bromelain on circulating inflammatory markers such as interleukin-6 and C-reactive protein was inconsistent, with some trials showing reductions and others detecting no difference.

Systematic review, 2025

Across the studies reviewed, bromelain was associated with improved blood sugar handling and insulin sensitivity markers in adults with raised blood sugar, though the human trial base was small.

Case-control, 2026

In adults with elevated liver fat, gene variants including one for a fat-processing enzyme were linked to liver measures, an association rather than a cause.

Randomised trial, 2019

In 26 children aged 18 to 23 months, adding phytase to a fortified porridge nearly doubled the zinc absorbed, from 0.5 mg to 1.1 mg.

Cohort study, 2025

In a cohort comparison rather than a randomised trial, the authors report substituting invertase for a sacrosidase oral solution in children with reduced intestinal sucrase activity managed in one clinical service, and describe the substitution as workable at lower cost in that setting. A single-service cohort report with no randomisation and no control group, so it does not establish an effect.

Systematic review, 2024

A review of randomised trials found the evidence for lactase drops shortening infant crying was inconsistent, with the better-designed trials detecting no difference.

Meta-analysis, 2024

Pooling randomised trials of lactase drops in unsettled infants, the reviewers did not detect a clear reduction in crying time, and the trials were small and varied in method.