O.N.E. Multivitamin.

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

• Studied in people22 human studies on Zinc back this formula, each one cited.
• A mechanism that is settledHow Vitamin A and Vitamin C work is settled pharmacology.
• Studied together, not just separatelyVitamin A and Vitamin E have been studied together, not only separately.
• Recent work on the recordThe most recent study on this record was published in 2026.
• Serving amount inside the studied rangeEach serving carries 400 mcg of Folate, inside the range the published research used.
• A stated daily maintenance amountFolate is here at a daily maintenance amount, which is what a daily supplement is for.
• Why this formatIt is a capsule, so the amount per serving is fixed and travels without measuring.
• The exact form, describedThe label names its forms exactly: Retinyl palmitate, Ascorbic acid, Vitamin K1 in an oil-filled softgel. The record says what each one is and what it suits.
• Where it comes from and how it is madeVitamin A is made by more than one route.
• Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
• A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
• Interaction screen on the recordEvery active on this label was screened against the interaction record, and the screen is published with it.

The combinations the trials actually measured.

Three pairings in this formula have been studied as combinations in human trials. Each finding below is what a named study measured, cited and dated, never written by the brand.

• Lutein + ZeaxanthinVision

  In the AREDS2 trial long-term follow-up, lutein and zeaxanthin taken together were associated with a modestly lower risk of progression to late age-related macular degeneration, while the trial original primary analysis was not significant.

  Chew et al., 2022 (JAMA Ophthalmology, AREDS2)PMID 35653117

  Promising
• Zinc + SeleniumImmune

  In a two-year trial in older adults, zinc taken together with selenium improved the antibody response to influenza vaccination.

  Girodon et al., 1999 (Arch Intern Med)PMID 10218756

  Early
• Folate + Vitamin B12 (Methylcobalamin) + vitamin-b6Heart

  In a 2025 network meta-analysis of 16 randomized trials in healthy adults, folic acid taken together with vitamins B6 and B12 lowered blood homocysteine more than any single supplement, with the 1 mg folic acid plus 7.2 mg B6 plus 20 micrograms B12 arm ranked most effective versus placebo (mean difference -1.03 micromol/L, 95% CI -1.71 to -0.36).

  Liu et al., 2025 (Nutrition Reviews)PMID 39960689

  Promising

Findings from trials that studied these actives as a combination. Context for how the actives were tested together, not a statement about any individual and not a claim about this product.

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

• Vitamin Cwithin 24 hours of a single doseMeasured within a day

  In a randomised crossover trial, 12 healthy adults consumed 101.7 mg of vitamin C as a powder, as raw fruits and vegetables, or as juice, and plasma vitamin C rose after every intake form, with plasma and urinary levels tracked over the 24 hours following the single dose.

  Choi et al., 2025 (Nutrients)PMID 41228404

  Strong
• Vitamin K1 (Phytomenadione)cleared from plasma within hoursMeasured within a day

  In a stable-isotope study, 10 healthy adults aged 22 to 31 took labelled vitamin K1 for six days and then an intravenous dose to resolve its disposal kinetics. Plasma vitamin K1 cleared with half-times of about 0.22 and 2.66 hours, and absorption of an oral dose was about 13 percent.

  Jones et al., 2008 (European Journal of Clinical Nutrition)PMID 17671443

  Promising
• Vitamin D3about 3 months of daily useBuilds with daily use

  In the trial record, blood vitamin D rises for about 3 months of daily vitamin D3 and then holds at a plateau, near 69 nmol/L at 1,000 IU a day, from a starting level near 41 nmol/L.

  Vieth et al., 2001 (Am J Clin Nutr)PMID 11157326

  Early
• Vitamin Eabsorbed slowly, tracked over 72 hoursMeasured within a day

  In a 3-phase crossover using two deuterium-labelled forms of alpha-tocopherol, healthy women absorbed about 55 percent of an oral dose taken with a 40 percent fat meal and about 64 percent with a fat-free meal, with samples tracked over 72 hours. The authors conclude absorption is not limited by absent fat or fasting, and that vitamin E leaves the intestine by a prolonged process.

  Traber et al., 2019 (American Journal of Clinical Nutrition)PMID 31495886

  Promising
• Vitamin B6 (Pyridoxine)about 4 weeks of daily useBuilds with daily use

  In a randomised crossover trial, 8 healthy young women using oral contraceptives took 100 mg of vitamin B6 daily for 4 weeks, and blood vitamin B6 status rose significantly after the 4-week supplementation period compared with the other measured time points, without staying elevated after the 4-week washout.

  C Curtin and Johnston, 2023 (Journal of dietary supplements)PMID 35109763

  Early
• Folatea median of about 36 weeks of daily intakeBuilds with daily use

  A systematic review and Bayesian meta-analysis drew on 108 articles from 14,002 screened records and modelled blood folate against folic acid intake using one-compartment pharmacokinetic models. Red blood cell folate rose 1.78 fold from baseline to steady state at 375 to 570 ug folic acid per day, and reaching that steady state took a median of 36 weeks, 95% credible interval 27 to 52 weeks. Serum or plasma folate rose 11.6% for every 100 ug per day of folic acid intake, 95% credible interval 8.4 to 14.9.

  Crider et al., 2019 (Nutrients)PMID 30609688

  Strong

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

How each ingredient usually behaves over time.

12 ingredients, from each one's own page.

• Vitamin AWeeks, not days

  Weeks to months. Liver stores buffer intake, so vitamin A status moves slowly and shows up on a blood panel rather than as a sensation.

  Its own page, the plain answer on timing ↗

• Vitamin CWithin hours

  Blood levels rise within hours and tissue pools fill over days. Collagen-linked changes in skin and gums build over weeks and show as tissue quality, not as a sensation.

  Its own page, the plain answer on timing ↗

• Vitamin K1 (Phytomenadione)Within days

  Clotting factor carboxylation responds within days, and circulating phylloquinone tracks what you ate this week. It reads on a lab measure rather than as a feeling.

  Its own page, the plain answer on timing ↗

• Vitamin K2 (MK-7)Four to twelve weeks

  For undercarboxylated osteocalcin to shift. It is a blood marker of carboxylation rather than something that registers as a sensation.

  Its own page, the plain answer on timing ↗

• Vitamin D3About six to twelve weeks

  25-hydroxyvitamin D climbs over roughly six to twelve weeks of daily dosing before it plateaus. It's a blood level you watch rather than a feeling.

  Its own page, the plain answer on timing ↗

• Vitamin EWeeks, not days

  Plasma alpha-tocopherol climbs within days of daily intake, and anything you'd notice in skin condition is a slow change across a couple of months.

  Its own page, the plain answer on timing ↗

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

The same ingredient, carried differently.

What each form is, and where it fits in a formula. Measured findings carry the study that reported them.

• Cholecalciferol (vitamin D3)

  The animal-sourced form of vitamin D, made in skin under UVB light and produced commercially from lanolin. Fat-soluble, so it travels with dietary fat and is stored in body fat.

  Fits

  Raising and holding vitamin D status, and the form most supplement trials use.

  Trade-off

  Being fat-soluble it accumulates with sustained high dosing, so intakes are set against the tolerable upper level rather than topped up freely.

  In a 12-week double-blind randomised controlled trial in 108 young women in urban Bangalore, most of whom began vitamin D-deficient, daily vitamin D3 at 400, 600 or 800 IU in a fortified wafer raised serum 25-hydroxyvitamin D, parathyroid hormone fell over time, and effects on bone-turnover markers were modest and not dose specific. The 800 IU dose brought 65 percent of participants to sufficiency.

  Peris et al., 2026 (Nutrients)PMID 42124077
• Riboflavin

  The unphosphorylated vitamin, a yellow orange crystalline solid with low water solubility

  Fits

  Dry dose forms such as tablets and capsules, where solubility matters less and cost per milligram is a consideration

  Trade-off

  Poorly soluble, so it is a difficult choice for a clear liquid, and it must be converted to FMN and FAD in the body before any enzyme can use it

• Pyridoxine hydrochloride

  The hydrochloride salt of pyridoxine, the alcohol-form vitamer of vitamin B6, a methylated pyridine ring carrying two hydroxymethyl groups and a ring hydroxyl, crystallised with hydrochloric acid.

  Fits

  A dry, freely water-soluble crystalline powder that stands up to heat and long storage, which makes it a workhorse for multivitamin tablets, fortified foods and powders, and high-throughput manufacturing.

  Trade-off

  It is a precursor vitamer rather than the coenzyme itself, so it relies on the body's own enzymes to phosphorylate and oxidise it into pyridoxal 5'-phosphate, the active form.

• Calcium L-methylfolate

  The calcium salt of (6S)-5-methyltetrahydrofolate, the same reduced folate that already circulates in blood, so it joins the folate cycle without passing through dihydrofolate reductase. Only the 6S (L) diastereomer is the biologically usable one. The calcium salt exists because free 5-MTHF oxidises quickly in air and light and needs a crystalline form that can survive being weighed, blended and pressed.

  Fits

  Fits prenatal and methylation-themed formulas where a brand wants the circulating form named on the panel, and lines aimed at shoppers who ask about MTHFR variants. It arrives as a free-flowing powder on a carrier, since the neat material is too potent to weigh at production scale, and it blends into capsules, tablets and stick packs. Pairs naturally with a blister or a tight HDPE pack with desiccant.

  Trade-off

  Raw-material cost per microgram runs well above folic acid, and the powder is sensitive to heat, humidity, light and oxygen, which constrains gummies and long ambient shelf lives. Label maths differs too: a microgram of this form is not a microgram of folic acid in dietary folate equivalents, and a panel that ignores the conversion overstates the dose. The human record is mostly folate-status endpoints rather than clinical outcomes.

  Double-blind, randomised, parallel-group trial in 172 healthy women aged 18 to 40, comparing an oral contraceptive combined with levomefolate calcium against the same contraceptive plus folic acid over 24 weeks, then 20 weeks of follow-up. Mean concentration-time curves for plasma folate, red blood cell folate and homocysteine were comparable between the two groups. After dosing stopped, median time for red cell folate to fall below 906 nmol per litre was 10 weeks (95 percent CI 8 to 12). The study was designed and authored by Bayer HealthCare staff.

  Diefenbach et al., Int J Womens Health 2013: folate status with levomefolate calcium versus folic acidPMID 23610531
• Methylcobalamin

  Cobalamin carrying a methyl group on the cobalt centre, the same species used directly by methionine synthase.

  Fits

  Oral tablets, capsules and powders where a preformed methylated cofactor is wanted.

  Trade-off

• Choline bitartrate

  Choline paired with L-(+)-tartaric acid as a crystalline, freely water-soluble salt.

  Fits

  Capsules, tablets and powders where a plain choline load is wanted and the tartrate acidity is acceptable.

  Trade-off

  A large share of the tablet weight is the tartrate counter-ion, so the label dose of salt is well above the choline it delivers.

3 more
Myo-inositol
The most common naturally occurring stereoisomer of inositol, a six-carbon sugar alcohol (cyclohexanehexol). It is the form found in most foods and in the body's own inositol pool, and is supplied as a free white crystalline powder.
Fits
It dissolves readily in water with a mild sweet taste, so it suits high-gram powders, stick packs and drink mixes where a large scoop needs to go into solution cleanly. It is also the form the bulk of inositol research has used.
Trade-off
Doses are counted in grams rather than milligrams, so it adds noticeable bulk to a capsule line and usually pushes a product toward a powder or several capsules per serving.
Ubiquinone
The oxidised, quinone form of coenzyme Q10: a fat soluble benzoquinone ring carrying a ten unit isoprenoid tail, supplied as a yellow orange crystalline powder made by yeast fermentation. It is the redox form nearly all CoQ10 raw material ships as, and the form used across the long running clinical trial record.
Fits
Formulas built on that historical trial record, including the cardiovascular outcome trials, which used the oxidised form. As a stable crystalline material it handles well in a factory without the oxygen excluding packing a reduced form asks for, and it goes into softgels, tablets, hard capsules and dry blends alike.
Trade-off
Oral absorption of CoQ10 in any redox form is low and depends heavily on the lipid matrix around it. The head to head crossovers against ubiquinol are small, short and single dose, so they settle little on their own.
Alpha-lipoic acid (racemic)
A 50:50 mixture of the R and S enantiomers of lipoic acid, sold as the free acid. The same molecule is also labelled thioctic acid.
Fits
A low-cost form to produce and the one used across most of the older clinical literature, which makes it a straightforward default for a general-purpose formula.
Trade-off
Half of the labelled material is the S enantiomer, which does not occur naturally, and as a free acid it can polymerise when exposed to heat or stomach acid.
In an open-label four-way crossover in 24 adults, a racemic solution produced higher peak plasma concentrations of both enantiomers than the 200, 300, and 600 mg tablet forms.
Hermann et al., 2014 (Clin Pharmacol)

Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.

Capsule

It is a capsule, so the amount per serving is fixed and travels without measuring.