Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Agastache urticifolia has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Agastache urticifolia belongs to Lamiaceae and its aerial parts carry a volatile oil made up largely of monoterpenes, with reported constituents including pulegone, menthone and limonene, though composition for this species is not consistently characterised across populations and harvests. Peppermint oil carries an overlapping monoterpene set. Combining two monoterpene-rich oils adds their load rather than introducing something new, which matters because pulegone in particular has a documented toxicity ceiling.
Rosmarinic acid is a caffeic acid ester found across the mint family, and Agastache species are consistently reported to contain it in their aerial parts. It is the phenolic behind most in vitro antioxidant readings from these plants. That is a laboratory measurement of radical scavenging, not a demonstrated effect in people.
Both are Lamiaceae aerial-part herbs prepared as infusions and both carry rosmarinic acid alongside a volatile oil. They appear together in calming tea blends because of tradition and flavour compatibility. Nothing about the combination has been formally examined.
Horsemint, the common name for Agastache urticifolia, was prepared as a beverage tea by Great Basin peoples including Paiute and Shoshone groups. Modern blends combine it with chamomile for a mild aromatic infusion. This is culinary and traditional practice, with no clinical work behind the pairing.
Piperine inhibits CYP3A4 and UGT enzymes, which slows the clearance of many plant constituents and raises their circulating levels. With a pulegone-containing volatile oil that is not a desirable direction, since pulegone toxicity depends on how much reaches the liver for CYP-mediated bioactivation. The pairing is worth flagging as one to avoid rather than to build.
Pulegone, present in several Agastache and Mentha species, is converted by liver CYP enzymes into menthofuran and then to reactive metabolites that deplete glutathione. Silymarin is studied for hepatic glutathione support. The reasoning is mechanistic and has not been tested with this plant, so read it as a rationale rather than a finding.
N-acetylcysteine supplies cysteine for glutathione synthesis, and glutathione is what conjugates the reactive metabolites formed from pulegone. This is established chemistry applied to a plant that has not been studied this way. The point is context for anyone using pulegone-rich mint oils at volume, not a recommended pairing.
Aromatic mint-family herbs and ginger appear together in traditional digestive infusions, both used for their carminative reputation. The combination is culinary convention across many food cultures. No controlled work exists on either the pairing or on Agastache urticifolia specifically for this use.
Nothing specific on file for Agastache urticifolia. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.Read this carefully. These are 29 voluntary, unverified reactions reported to the FDA (openFDA). The number mostly reflects how popular Agastache urticifolia is, not how risky it is. A report is not proof Agastache urticifolia caused anything. It is a signal of what to watch for, nothing more.
Source: openFDA adverse-event reports. Voluntary reporting, not an incidence rate.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.