Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Butylphthalide has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Li and colleagues found that disrupting the intestinal microbiota with antibiotics changed measured butylphthalide exposure in vivo. That implicates microbial metabolism or microbially influenced absorption in how much of a dose is available. Anything that reshapes the gut community, including antibiotics and probiotic use, is therefore a plausible source of variability.
The compound is formulated in soft capsules dissolved in vegetable oil because it will not dissolve in water. A defined medium chain triglyceride vehicle gives more consistent dispersion than relying on stomach contents. This affects exposure, not intrinsic activity.
Butylphthalide has been described as reducing platelet aggregation in laboratory work, and high dose EPA and DHA do the same through eicosanoid substrate competition. Stacking them adds bleeding risk, particularly alongside prescribed antiplatelet medicines. This pairing belongs on a caution list.
Ginkgo terpene lactones antagonise platelet activating factor and butylphthalide has its own reported antiplatelet activity. The combination is popular in the same product category, which is exactly why the overlap deserves flagging. There is no controlled human work on the pair.
The metabolic work by Lu and colleagues points toward mitochondrial and energy metabolism effects in a rodent model. Coenzyme Q10 sits directly in the electron transport chain. The overlap is mechanistic and animal derived, so read it as a hypothesis rather than as a clinical pairing.
Ligustilide and butylphthalide belong to the same phthalide family and share structural features. Traditional Angelica preparations therefore supply chemically related molecules from a different plant source. Structural relatedness is not the same as equivalent activity, and the two should not be dose compared.
Nothing specific on file for Butylphthalide. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.These are the studies our verdict leans on, chosen from the 3 we read for Butylphthalide. The full linked list is below.
12 sources behind our Butylphthalide verdict: peer-reviewed studies and registered clinical trials. Every one links straight to PubMed, the journal, or ClinicalTrials.gov. Read them yourself.
Evidence surfaced via Semantic Scholar (Allen Institute for AI) and ClinicalTrials.gov. Ranked by study type and citation weight, not cherry-picked.
Read this carefully. These are 262 voluntary, unverified reactions reported to the FDA (openFDA). The number mostly reflects how popular Butylphthalide is, not how risky it is. A report is not proof Butylphthalide caused anything. It is a signal of what to watch for, nothing more.
Source: openFDA adverse-event reports. Voluntary reporting, not an incidence rate.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.