Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Lady's Mantle has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
This is the same mechanism by which strong tea reduces iron uptake from a meal, and it is one of the better characterised food interactions in nutrition. Separating the two by a couple of hours largely avoids it. The effect is on absorption from that meal, not on iron stores directly.
Stacking tannin sources raises the total protein and mineral binding capacity in the gut. That increases astringency and the likelihood of gastric discomfort. Worth counting as one load rather than two ingredients.
The evidence base for zinc is thinner than for iron but the chemistry is the same. Anyone taking a tannin rich herbal preparation with a mineral supplement should space them. This is a timing point, not a reason to avoid either.
Tannin protein complexes form readily in the stomach and reduce the protein available for digestion in that meal. The size of the effect at herbal tea intakes is modest. It is more relevant to the mouthfeel of a formulation than to nutrition.
This is the standard countermeasure when a tannin rich beverage or herb is taken with a plant iron source. It does not fully cancel strong tannin inhibition but it shifts the balance meaningfully. The interaction is well described for tea and coffee and applies by the same chemistry here.
Long usage supports tolerability but says nothing about efficacy. No controlled work has separated the components of these traditional blends. The pairing is heritage and should be described as such.
The rationale is mechanically sensible: mucilage coats, tannin contracts. Neither the combination nor its individual claims have been tested in controlled human work. Regard it as formulation convention with a plausible physical basis.
Combining two polyphenol dense preparations multiplies the astringency and the mineral binding without any established added benefit. Concentrated green tea extract also carries its own hepatic caution at high doses. Count the total polyphenol load, not the number of ingredients.
Both are conjugated by the same phase two glucuronidation and sulfation routes, which are saturable. The amounts from a herbal infusion are small next to a supplemental quercetin dose. This is dose accounting rather than a meaningful interaction.
The binding affinity of hydrolysable tannins for proline rich sequences is the classic model system in tannin chemistry. Complexed peptide is less available for absorption in that meal. Spacing the two apart resolves it.
Nothing specific on file for Lady's Mantle. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.These are the studies our verdict leans on, chosen from the 1 we read for Lady's Mantle. The full linked list is below.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.