Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Lime has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Citrate forms a soluble complex with calcium ions, which keeps calcium in solution rather than letting it pair with oxalate or carbonate. This is why calcium citrate exists as a salt and why citrate appears in urinary chemistry discussions at all. The relationship is chemical and predictable, and it works in the other direction too: high citrate loads change how a calcium dose behaves in the gut and in urine.
Non-heme iron is absorbed far better in the reduced ferrous state, and the ascorbate plus citric acid in lime juice both reduces it and holds it in solution as the gut contents turn alkaline. This is one of the oldest and most reproducible food-matrix effects in nutrition. Taking a plant-source iron supplement with citrus juice rather than with tea or coffee follows directly from it.
Citrate keeps magnesium soluble across the pH shift from stomach to small intestine, which is why the citrate salt is one of the better-dissolving magnesium forms. A citrate-rich juice supplies the same anion in free form. The effect is on solubility, which is a precondition for absorption rather than a guarantee of it.
Calcium carbonate dissolves poorly without stomach acid, which is why it is normally taken with food. An acidic citrus load provides the same protonation help. This matters most for people with low stomach acid, where carbonate otherwise passes through largely undissolved.
Fresh lime juice supplies ascorbic acid, though the amount varies with variety, ripeness and how the juice was processed. Heat-treated and concentrated lime products lose much of it. Anyone counting on lime for vitamin C should count the supplement dose alongside it rather than instead of it.
Organic acids form soluble complexes with zinc, which can help solubility but also competes with the ligands a zinc salt was formulated around. The net direction depends on the zinc form and the amount of acid present. Read this as a formulation variable to test rather than a settled enhancement.
Adding isolated ascorbic acid to a lime preparation stacks the same compound the fruit already contributes. It also deepens the iron-solubilising effect described for the iron pairing. There is no separate mechanism at work, only a larger dose of one.
Nothing specific on file for Lime. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.These are the studies our verdict leans on, chosen from the 2 we read for Lime. The full linked list is below.
4 sources behind our Lime verdict: peer-reviewed studies and registered clinical trials. Every one links straight to PubMed, the journal, or ClinicalTrials.gov. Read them yourself.
Evidence surfaced via Semantic Scholar (Allen Institute for AI) and ClinicalTrials.gov. Ranked by study type and citation weight, not cherry-picked.
Read this carefully. These are 141 voluntary, unverified reactions reported to the FDA (openFDA). The number mostly reflects how popular Lime is, not how risky it is. A report is not proof Lime caused anything. It is a signal of what to watch for, nothing more.
Source: openFDA adverse-event reports. Voluntary reporting, not an incidence rate.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.