Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Paeonia moutan has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Moutan cortex appears with gan cao across classical multi-herb formulas, where licorice is used as a harmonising and taste-modifying constituent. The pairing is documented in formulary practice rather than in controlled comparison against moutan alone. Licorice also carries its own effect on potassium and blood pressure at sustained intakes, which is the more consequential half of this combination.
Moutan cortex and dang gui co-occur in several long-standing gynaecological formulas. What is documented is the formula, not the pair, so no separate contribution can be assigned to either herb. Both have been described as affecting platelet function in laboratory work, so the pairing also carries an additive bleeding consideration.
Paeonol, the marker phenolic of moutan cortex, reduces platelet aggregation in cell-free and animal systems. High-dose EPA and DHA shift platelet function in the same direction in people. No human study has looked at the combination, so this is a mechanistic flag on direction rather than a measured interaction.
Both moutan cortex constituents and gingerols have shown antiplatelet activity in laboratory preparations. Neither result has been established as a clinical effect at culinary or supplement intakes. The pairing is listed for the direction it points, not for a benefit.
Paeoniflorin is a monoterpene glycoside, and gut bacterial glycosidases release the aglycone before meaningful absorption occurs. Interindividual differences in that microbial step are one reason exposure varies between people given the same amount. Whether a defined probiotic raises that conversion in humans has not been demonstrated.
Moutan cortex carries tannins including paeonolide-associated polyphenols and gallotannins, which bind non-haem iron in the gut lumen and form poorly absorbed complexes. Taking the bark preparation at the same time as an iron supplement lowers the iron that gets through. Separating them by two hours removes most of the overlap.
Nothing specific on file for Paeonia moutan. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.These are the studies our verdict leans on, chosen from the 4 we read for Paeonia moutan. The full linked list is below.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.