About 46% of US adults
take in less vitamin C than the estimated average requirement.
Peer-reviewed analysisOrganic Pea Protein is the lead active here, studied most for strength. In the 3 g Organic Pea Protein Blend with one other, listed first. Magnesium is the most studied active here, with 21 human studies behind it, each one cited. Each serving carries 1.7 mg of Riboflavin, inside the range the published research used. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 29 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Stronger in a pair".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 2,889 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
About 46% of US adults
take in less vitamin C than the estimated average requirement.
Peer-reviewed analysisAbout 48% of Americans
take in less magnesium than recommended from food and drink.
NIH Office of Dietary SupplementsMore than 1 in 3 US adults
regularly sleep less than the recommended seven hours a night.
Peer-reviewed analysisRandomised trial, 2021
In trained adults, beetroot juice supplementation improved some aerobic and anaerobic performance measures, with mixed results on cognitive tests.
International Journal of Environmental Research and Public HealthClinical trial, 1990
In people with weak, splitting nails, oral biotin increased nail thickness by about 25 percent under scanning electron microscopy and the nail surface became more regular.
Journal of the American Academy of DermatologyMeta-analysis, 2022
Across 24 trials in 1,325 adults with high blood sugar, magnesium at about 300 mg daily for four months lowered fasting glucose 0.20 mM and HbA1c 0.22 percent.
Frontiers in NutritionRandomised trial, 2026
A low dose of lemon myrtle supplementation was reported to increase hypertrophy measures during low-load resistance training in older adults. Again Backhousia citriodora, not Citrus limon.
Journal of Aging ResearchSystematic review, 2024
Across exercise studies, magnesium was linked to less muscle soreness and better recovery, with people training hard possibly needing 10 to 20 percent more than sedentary people.
Journal of Translational MedicineMeta-analysis, 2025
In a network meta-analysis of 19 trials with 1,658 participants, biotin-containing preparations were among the supplements linked to greater hair density, though most individual trials were small.
Frontiers in nutritionMeta-analysis, 2025
Across over 20 trials, magnesium raised HDL cholesterol by about 1.2 mg/dL but showed no clear change in LDL, total cholesterol or triglycerides.
Nutrition JournalRandomised trial, 2019
In adults with elevated blood sugar, an amla fruit extract for 12 weeks improved a blood vessel lining function measure and lowered oxidative stress and inflammation markers versus placebo.
BMC complementary and alternative medicineSystematic review, 2017
Across 18 reported cases, all involving an existing deficiency or related condition, hair and nail growth improved after biotin, with limited evidence of benefit in people who are not deficient.
Skin Appendage DisordersRandomised trial, 2025
In adults with excess body weight, amla extract was followed by modest reductions in body mass index, waist circumference and total and visceral body fat compared with placebo.
Complementary medicine researchRandomised trial, 2025
Daily lemon verbena extract was reported to change subjective energy ratings against placebo on questionnaire endpoints. The botanical studied is Aloysia citriodora, not lemon fruit.
Journal of PsychopharmacologyRandomised trial, 2020
Nitrate-rich beetroot juice lowered blood pressure in Tanzanian adults with elevated blood pressure compared with nitrate-depleted juice.
The Journal of NutritionRandomised trial, 2015
In adults carrying cardiovascular risk factors, twelve weeks of a standardised Phyllanthus emblica extract improved lipid measures and lowered platelet aggregation, both laboratory measures.
Journal of medicinal foodRandomised trial, 2012
In 46 older adults with poor sleep, eight weeks of magnesium improved their scores on a sleep questionnaire against placebo.
older adults with poor sleepRandomised trial, 2026
In one trial, 20 adults on an antidepressant added magnesium, and low mood scores changed over six weeks, with the antidepressant doing part of the work by design.
East Asian Archives of PsychiatryMeta-analysis, 2016
Across 10 trials, magnesium reduced how often severe recurring headache attacks struck.
Pain PhysicianSystematic review, 2025
A review of beetroot juice trials in older adults reported improvements in physical performance measures, with cognitive findings less consistent.
NutrientsRandomised trial, 2025
Lemon myrtle extract taken alongside low-load bodyweight resistance training was reported to increase muscle size measures in older adults relative to training alone. Lemon myrtle is Backhousia citriodora, a different plant from lemon fruit.
The Journal of Nutrition, Health and AgingSystematic review, 2026
Long-term plant versus animal protein supplementation was examined for body composition, muscle strength and physical performance, with the authors reporting on duration as a factor in the observed effects.
Frontiers in NutritionSystematic review, 2026
The analysis compared combinations of protein source and exercise modality to describe which pairings carried the larger reported effects on the outcomes examined.
NutrientsMeta-analysis, 2016
Pooling 34 trials, magnesium lowered the top blood pressure number by about 2 mmHg.
The paperMeta-analysis, 2025
Across 38 trials, magnesium lowered the top blood pressure number by about 2.8 mmHg and the bottom number by about 2.1 mmHg, with bigger drops in people who started with low blood magnesium.
The paperMeta-analysis, 2022
Blueberry supplementation improved some components of metabolic health in pooled trials, with the effect differing by marker.
Food & functionSystematic review, 2025
Pooling human trials of apple cider vinegar, the review found small reductions in body weight and waist measures in adults with raised blood sugar or excess body weight, and described the evidence base as limited.
NutrientsSystematic review, 2025
Across the trials pooled, plant proteins were used for recovery from resistance-exercise-induced muscle damage in healthy young adults, with the authors summarising the range of reported effects rather than a single figure.
NutrientsRandomised trial, 2013
In adults with elevated blood pressure carrying the MTHFR 677TT genotype, riboflavin 1.6 mg per day lowered systolic blood pressure by about 5.6 mmHg versus placebo over 16 weeks.
The paperMeta-analysis, 2023
Pooling human trials, Lycium barbarum supplementation was associated with modest reductions in total cholesterol and triglycerides in adults, with variation across studies.
MedicineCohort study, 2026
Reports an association between dietary thiamin, riboflavin and niacin intake and elevated blood pressure and pulse pressure. An association in intake data, not a demonstration of cause.
MedicineMeta-analysis, 2023
Pooling randomised trials, amla supplementation was associated with lower total and LDL cholesterol, lower fasting blood sugar and lower C-reactive protein than control, all of which are laboratory markers rather than health outcomes.
The paperRandomised trial, 2011
In 22 healthy volunteers, four weeks of tulsi leaf extract raised several immune system markers compared with placebo, laboratory markers rather than measured health outcomes.
Journal of EthnopharmacologyRandomised trial, 2024
A randomised controlled trial characterised the sugar composition of Thai desserts and measured shifts in gut microbiome composition in healthy volunteers consuming them.
NutrientsRandomised trial, 2026
Animal- and plant-derived protein supplementation shifted gut microbial community structure and predicted metabolic potential. These are microbiome measurements, not clinical outcomes.
NutrientsRandomised trial, 2023
A trial of a goji berry mouthwash reported changes in plaque and gum inflammation scores versus a comparator rinse, clinical measures of gum tissue rather than a systemic outcome.
F1000ResearchRandomised trial, 2016
In healthy adults, a single serving of Psidium guajava fruit juice was followed by lower platelet aggregation in blood samples taken after intake than at baseline, a laboratory marker rather than a clinical outcome.
BMC complementary and alternative medicineCohort study, 2010
In volunteers, a supplement containing goji berry was followed by more circulating stem and progenitor cells, an uncontrolled observation that cannot show the berry caused it.
Journal of translational medicineSystematic review, 2026
The review found that reported responsiveness to riboflavin across inherited disorders of metabolism is uneven and rests largely on small series, so the strength of evidence varies by the specific condition.
Journal of Inherited Metabolic DiseaseMeta-analysis, 2025
Across trials, blueberries produced small improvements in memory and executive function measures.
BiogerontologyRandomised trial, 2022
In 100 adults under stress, 125 mg of a standardised Ocimum sanctum extract twice daily for 8 weeks lowered perceived stress scores (p = 0.003) and sleep-difficulty scores (p = 0.025) and left hair cortisol lower at week 8 (p = 0.025) compared with placebo.
Frontiers in NutritionRandomised trial, 2015
Thirty days of 300 mg a day of ethanolic holy basil leaf extract shortened reaction times and lowered error rates on memory and attention tasks compared with placebo in healthy adults, with no change detected in heart rate or skin conductance.
Indian Journal of Physiology and PharmacologyRandomised trial, 2020
A controlled trial tested sugar cane flour, a fiber-containing whole cane fraction rather than refined sugar, against self-reported upper digestive comfort.
NutrientsRandomised trial, 2019
A flavonoid-rich mixed berry drink was tested against a matched control on cognitive test performance across a six hour window in healthy young adults. Goji is named only as one component of the wider berry literature, so this is not evidence for goji on its own.
NutrientsSystematic review, 2026
A systematic review of dietary flavonoids and mood that includes berry anthocyanin trials. The authors report mixed results across a heterogeneous set of studies.
Nutrition ReviewsMeta-analysis, 2024
In a dose-response meta-analysis of randomised trials, riboflavin was associated with about 1.3 fewer severe recurring headache attacks per month compared with control.
Neurological SciencesNarrative review, 2024
The review documents long-standing traditional use of Psidium guajava leaf preparations for gastrointestinal complaints and describes tannin and flavonoid constituents that reduce intestinal motility and secretion in laboratory models.
Frontiers in PharmacologySystematic review, 2025
The review compared plant against animal protein on muscle mass, strength and physical performance and did not detect a clear separation between the sources in the trials available, which is a failure to detect a difference within the limits of that evidence base rather than a demonstration that the sources are equivalent.
Nutrition ReviewsSystematic review, 2025
An umbrella review of water-soluble vitamins, biotin among them, found only small and inconsistent changes in blood sugar and insulin sensitivity measures in adults with raised glucose.
Asia Pacific journal of clinical nutritionRandomised trial, 2025
A plant-based protein blend and an animal-based comparator produced similar muscle adaptation results. No difference was detected between them, which is not the same as showing they are identical.
Journal of the International Society of Sports NutritionMeta-analysis, 2017
Across randomised trials, blueberry supplementation did not produce a detectable change in systolic or diastolic blood pressure.
The paperRandomised trial, 2019
Thiamin supplementation did not improve left ventricular ejection fraction in the participants studied. This is a failure to detect a difference in an imaging marker, not evidence that no difference exists.
The American Journal of Clinical NutritionRandomised trial, 2021
Adding baobab fruit pulp to the diet did not produce a detectable improvement in haemoglobin levels in the group studied.
European journal of nutritionSystematic review, 2023
Across 18 studies, pyridoxine on its own and in combinations improved nausea scores in pregnancy on both the Rhode and PUQE scales, a use with a long clinical track record.
Archives of Gynecology and ObstetricsMeta-analysis, 2025
A nutrition-status analysis in children included thiamin among the micronutrients measured, reporting intake and status data rather than a result of giving supplements.
Journal of Human Nutrition and DieteticsRandomised trial, 2026
Thiamin supplementation improved the thiamin pyrophosphate effect, a blood marker of thiamin adequacy, in children whose levels were low.
Scientific reportsRandomised trial, 2023
Across several centres, infant formula supplemented with biotin raised infants' blood biotin levels into the range seen with adequate intake.
Pediatrics internationalMeta-analysis, 2021
Pooling nine controlled trials in 673 people, vitamin B2 at 400 mg per day for three months lowered the frequency, days, duration and pain score of severe recurring headache attacks.
Nutritional NeurosciencePopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
One pairing in this formula has been studied as a combination in human trials. Each finding below is what a named study measured, cited and dated, never written by the brand.
In an 8-week randomized trial of 264 stressed healthy adults with low magnesium, magnesium plus vitamin B6 and magnesium alone reduced perceived stress about equally overall. In the prespecified subgroup that started with severe stress, the combination improved stress scores 24% more than magnesium alone.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Fail closed. Where actives were studied on their own rather than together, each shows on its own evidence, never a combined effect no trial measured.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
Findings from trials that studied these actives as a combination. Context for how the actives were tested together, not a statement about any individual and not a claim about this product.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In a randomised crossover trial, 12 healthy adults consumed 101.7 mg of vitamin C as a powder, as raw fruits and vegetables, or as juice, and plasma vitamin C rose after every intake form, with plasma and urinary levels tracked over the 24 hours following the single dose.
In the controlled depletion study the EFSA reference opinion reviews, restricting thiamin intake to 0.009 to 0.015 mg/MJ for 30 days brought urinary free thiamin excretion from a mean of 0.283 mg/24 h down to undetectable levels by day 18 of the depletion period.
In the same depletion and repletion record the EFSA reference opinion reviews, erythrocyte transketolase activity fell progressively to about 75% of baseline during the 30-day depletion period and returned to its baseline value after 1 week of thiamin repletion.
In an intervention the EFSA reference opinion reviews, adults whose baseline riboflavin intake and status were unknown received 5 mg/day of riboflavin for 8 weeks, and haemoglobin concentration, haematocrit and erythrocyte count all rose significantly over that period.
An expert consensus on vitamin B6 use, developed by a six-member Delphi panel with a structured evidence-quality assessment, calculated from pharmacokinetic parameters that complete clearance of vitamin B6 from the body takes a washout period of about 20 to 40 days after intake stops.
A systematic review and Bayesian meta-analysis drew on 108 articles from 14,002 screened records and modelled blood folate against folic acid intake using one-compartment pharmacokinetic models. Red blood cell folate rose 1.78 fold from baseline to steady state at 375 to 570 ug folic acid per day, and reaching that steady state took a median of 36 weeks, 95% credible interval 27 to 52 weeks. Serum or plasma folate rose 11.6% for every 100 ug per day of folic acid intake, 95% credible interval 8.4 to 14.9.
A kinetic study in six healthy men aged 22 to 31 gave 3.6 umol per day, 1.6 mg, of deuterium-labelled folic acid for four weeks, with folate tracked in serum, erythrocytes and urine by microbiological assay and gas chromatography mass spectrometry. Serum folate reached its maximum concentration in about 18 days, while isotopic labelling of erythrocyte folate kept rising across the whole four weeks. After supplementation stopped, red blood cell folate and urinary folate excretion declined linearly, and serum folate fell with a slow-phase half-life of 18.7 days. One study, six men, no control group.
In an open trial with no placebo arm, 71 patients with brittle or splitting fingernails took 2.5 mg of biotin a day. Of the 45 cases that could be evaluated, 41 were rated as having firmer and harder nails after an average of 5.5 months of treatment, standard deviation 2.3 months. The rating was clinical judgement rather than an instrument reading, and there was no control group, so the window describes when the raters recorded change, not a placebo adjusted effect.
In an 84-day randomised trial, sedentary adults took pea protein or whey protein daily alongside a weekly resistance training programme. The pea protein group improved whole-body muscle strength by 16.1 percent from baseline, and no significant between-group differences appeared in strength, muscle mass or product perception.
In a small preliminary study, nine older adults with early age-related memory changes drank wild blueberry juice daily for 12 weeks and improved on paired-associate learning and word-list recall, with scores compared against a demographically matched group given a berry placebo drink. One study of nine people, juice rather than a capsule.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
12 ingredients, from each one's own page.
Blood levels rise within hours and tissue pools fill over days. Collagen-linked changes in skin and gums build over weeks and show as tissue quality, not as a sensation.
There is no onset to time in the usual sense. Status markers such as erythrocyte transketolase activity move across weeks, and that is where the change is read.
Urine turns bright yellow within hours of the first dose. Status itself, read as red cell glutathione reductase activity, shifts across two to eight weeks.
Nothing to wait for at everyday amounts. Niacin status shows up on blood work rather than as a sensation. The flush from the nicotinic acid form arrives within 30 minutes.
Nothing quick. Conversion to the active coenzyme happens within hours, but plasma pyridoxal 5-phosphate takes a couple of weeks to settle at a new level.
Red cell folate climbs over roughly four to eight weeks. It's a blood panel change rather than a sensation.
Fingernails grow around 3mm a month, so it takes roughly 8 to 12 weeks before enough new plate has grown out to judge the difference by eye.
There's no onset you would time. It feeds coenzyme A within days, and the effect sits in metabolism and blood levels rather than in a sensation.
A looser stool can turn up the same day at the higher end. Sleep and cramp changes usually settle in across two to four weeks, because it is refilling a body-wide store.
Sweetness is immediate, and the glucose half reaches your blood within about fifteen to thirty minutes. There is no slower effect building behind it.
There is nothing to wait for. At colour amounts the change is on the surface of the tablet or powder rather than anywhere in you.
Give it eight to twelve weeks. That is the window trials used to read lipid and inflammatory markers, so the change lands on a panel rather than in how you feel.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
The free vitamin B2 molecule, an isoalloxazine ring joined to a ribitol sugar chain, supplied as the unmodified crystalline compound with no added salt or phosphate group.
The free-acid form of vitamin B3, pyridine-3-carboxylic acid. It is the reference form of niacin, a small water-soluble molecule carrying a bare carboxylic acid group on the pyridine ring.
The free acid form of vitamin B5, an amide of pantoic acid and beta-alanine, supplied as a viscous hygroscopic oil or a stabilised liquid rather than a dry salt.
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
It is a powder, so the serving scales to the amount you want and mixes into something you already drink.
Where two of this brand's products carry actives the literature has read together, the pairing and its basis are below. The evidence word is the corpus row's own confidence, never a score.
Vitamin C increases iron absorption up to 6x by keeping it in ferrous form.
Hallberg L, Brune M, Rossander L. Int J Vitam Nutr Res Suppl. 1989;30:103-108.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.