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Strong evidence, strong doseGorilla Mind, verified Oct 2026Formula verified. Independently reviewed.Independent review. Not commissioned by Gorilla Mind.

L-Citrulline is the lead active here, studied most for oxygen delivery to working muscle. 16 human studies on L-Citrulline back this formula, each one cited. Each serving carries 4,500 mg of L-Citrulline, inside the range the published research used. Who it fits: for everyone, adults.

Clinically dosedFull label disclosure
12Active ingredientsWell studiedResearch base68Human studies
Gorilla ModeVerified by IngredientMD
Gorilla MindIngredientMD
The verdict
Strong evidence, strong dose
For everyone, adults.
How we verify

The brand submits the formula. We read the supplement facts panel and weigh dose, form and synergy against the clinical evidence. Labs test. IngredientMD verifies. The fee pays for review time, never for the outcome.

The formula
L-Citrulline: Oxygen delivery to working muscleKey driver
Creatine Monohydrate: StrengthExtensively studied
GlycerPump: EnduranceSupporting role
Malic Acid: Cellular energy productionSupporting role
Betaine Anhydrous: StrengthWell studied
L-Tyrosine: Focus and clear thinkingExtensively studied
Agmatine Sulfate: Physical performanceSupporting role
Kanna (Sceletium Tortuosum): Focus and clear thinkingSupporting role
Caffeine Anhydrous: Physical performanceExtensively studied
N-Phenethyl Dimethylamine Citrate: Physical performanceSupporting role
Bioperine: Filling everyday nutrient gapsWell studied
Huperzine A (Huperzia serrata leaf standardized extract): Holding attention on one thingWell studied
Visit the brand

How we read this product

Source: Supplement facts
Supplement Facts panel for Gorilla Mode
  1. 01
    We read the label.

    The panel on the left is the one we evaluated, line by line.

  2. 02
    Every active, separately.

    All 12 actives checked against the clinical evidence: dose, form, and what the research actually shows.

  3. 03
    Then the formula as a whole.

    Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".

  4. 04
    Earned, not bought.

    The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.

Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.

The receipts

Well studied
Research base
68
Human studies
4500 mg
L-Citrulline
2500 mg
Creatine Monohydrate
4.5 g per serving sits inside the studied 3 g-6 g range
L-Citrulline, Perez-Guisado 2010 + Bailey 2015 exercise study
2.5 g per serving sits inside the studied 2 g-5 g range
Creatine Monohydrate, Kreider et al. 2017 ISSN Position Stand (n=1,847 across meta-analyses)
1,250 mg per serving sits inside the studied 1,250 mg-2.5 g range
Betaine Anhydrous, Cholewa 2018 systematic review + Trepanowski 2011
750 mg per serving sits inside the studied 500 mg-1 g range
L-Tyrosine, Jongkees 2015 meta + Mahoney 2007 military study

Cross-checked against 1,576 documented interactions for these actives.

Read the evidenceL-Citrulline, the evidence →Creatine Monohydrate, the evidence →GlycerPump, the evidence →Malic Acid, the evidence →Betaine Anhydrous, the evidence →L-Tyrosine, the evidence →

Inside the formula

L-Citrulline
16 studies
Oxygen delivery to working muscle
Studied 3 g to 10 g a day
Key driver
Creatine Monohydrate
22 studies
Strength
Studied 2 g to 10 g a day
Extensively studied
GlycerPump
Endurance
Supporting role
Malic Acid
Cellular energy production
Supporting role
Betaine Anhydrous
Strength
Well studied
L-Tyrosine
10 studies
Focus and clear thinking
Studied 500 mg to 2 g a day
Extensively studied
Agmatine Sulfate
Physical performance
Studied 500 mg to 2.5 g a day
Supporting role
Kanna (Sceletium Tortuosum)
Focus and clear thinking
Supporting role
Caffeine Anhydrous
Physical performance
Extensively studied
N-Phenethyl Dimethylamine Citrate
Physical performance
Supporting role
Bioperine
Filling everyday nutrient gaps
Studied 5 mg to 20 mg a day
Well studied
Huperzine A (Huperzia serrata leaf standardized extract)
Holding attention on one thing
Well studied
In context

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

The people it speaks toFieldwork 2023

21.1% of the US population

aged 15 and over took part in sports, exercise, or recreation on an average day in 2023, in the American Time Use Survey.

US Bureau of Labor Statistics, 2024
This formulaNHANES 2017-2018, published 2021

57.6%

During 2017 to 2018, 57.6% of US adults aged 20 and over reported using a dietary supplement in the past 30 days.

CDC National Center for Health Statistics
36 more
Daily use

59 to 66 days

was the median time it took adults to make a new daily health habit automatic across the studies a 2024 review pooled, with individuals ranging from 4 to 335 days.

Systematic review and meta-analysis, 2024
Creatine Monohydrate

Meta-analysis, 2017

In older adults doing resistance training, adding creatine increased lean tissue mass by about 1.37 kg and produced greater chest and leg press strength than training alone across 22 trials.

Open Access Journal of Sports Medicine
Caffeine Anhydrous

Randomised trial, 2026

In 38 active men, caffeine before a 10 km run or 40 km cycling improved completion time by 1.8 percent, though a gene difference in caffeine levels didn't affect performance.

European Journal of Sport Science
L-Citrulline

Meta-analysis, 2025

Pooling 8 trials in 176 middle-aged and older adults, l-citrulline improved how well blood vessels widen by about 1.8 percentage points, with no clear change in artery stiffness.

Frontiers in Nutrition
Betaine Anhydrous

Meta-analysis, 2024

Pooling 17 trials in 317 healthy adults, at least 7 days of betaine raised maximal strength with a standardized effect of 0.47, most clearly in the lower body.

Journal of Sports Sciences
Creatine Monohydrate

Systematic review and meta-analysis, 2023

Across 8 randomized trials, creatine improved memory performance in healthy people, with the largest effect in adults aged 66 to 76.

Nutrition Reviews
Caffeine Anhydrous

Systematic review, 2019

Across 10 studies at matched doses, caffeine gave similar aerobic and fatigue benefits to men and women, while 4 of 7 studies found bigger strength and sprint gains in men.

Nutrients
Caffeine Anhydrous

Meta-analysis, 2022

Across 21 trials at 3 to 9 mg per kg, caffeine lengthened time to exhaustion in running and shortened race completion time compared with placebo.

Nutrients
Creatine Monohydrate

Systematic review, 2026

A comparison of protein, creatine and omega-3 found each supported muscle strength and endurance outcomes to a different degree alongside training.

Nutrients
Creatine Monohydrate

Randomised trial, 2025

In 40 healthy men and women, 33 days of creatine before a muscle-damaging workout sped up strength recovery, with less stiffness and fatigue, and less swelling in the women.

Nutrients
Caffeine Anhydrous

Systematic review, 2021

Across 37 blinded crossover studies, caffeinated drinks improved several aspects of sports performance once the drink supplied at least 3 mg of caffeine per kg of body mass.

Nutrients
L-Tyrosine

Controlled human trial, 1999

One hour after a 150 mg/kg dose, tyrosine held working-memory accuracy higher while participants juggled several tasks at once, compared with placebo, with no change on the simpler single-task version.

Pharmacology, Biochemistry, and Behavior
Creatine Monohydrate

Randomised trial, 2022

In 8 healthy adults taking 5 grams of creatine monohydrate daily for 14 days, muscle creatine content rose, while creatyl-L-leucine at the same dose produced no change.

International journal of sport nutrition
L-Tyrosine

Randomised trial, 2020

In 9 older and 9 young adults cooled for 90 minutes, 150 mg per kg of oral l-tyrosine more than doubled skin vessel narrowing in older adults and helped hold core temperature.

Medicine and Science in Sports and Exercise
L-Citrulline

Systematic review and meta-analysis, 2019

Across 8 trials, L-citrulline lowered the top blood pressure number by about 4 points, with a drop in the bottom number only at doses of 6 grams a day or more.

Avicenna Journal of Phytomedicine
L-Citrulline

Meta-analysis, 2025

Across 15 trials in middle-aged and older adults, l-citrulline or watermelon intake lowered blood pressure by about 4 points on the top number and about 2.5 points on the bottom number.

Clinical Nutrition ESPEN
Caffeine Anhydrous

Systematic review, 2010

In a Cochrane review of 13 randomized trials in shift workers, caffeine improved orientation and attention (SMD -0.55) and reduced the number of errors made during simulated night or shifted work versus placebo.

Cochrane Database of Systematic Reviews
Huperzine A (Huperzia serrata leaf standardized extract)

Systematic review, 2024

A systematic review of natural compounds taken over months for cognitive performance includes huperzine A among those linked to better scores on cognitive tests in older adults, with few and small trials behind it.

Frontiers in aging neuroscience
L-Tyrosine

Double-blind placebo-controlled crossover trial, 1989

During 4.5 hours of combined cold and low-oxygen exposure, a single 100 mg/kg dose of tyrosine reduced stress symptoms, low mood, and performance decline in the people who reacted most to the conditions.

Brain Research Bulletin
L-Tyrosine

Systematic review, 2015

Across the human cognitive and behavioral trials, tyrosine reliably supported working memory and cognitive control during short-term demanding or stressful conditions, with little added benefit when neurotransmitter demand was not raised.

Journal of Psychiatric Research
Huperzine A (Huperzia serrata leaf standardized extract)

Randomised trial, 2020

A multi ingredient pre workout containing huperzine A shifted the balance of energy systems used and improved performance during high intensity exercise, again as a whole blend rather than a single ingredient test.

Journal of the International Society of Sports Nutrition
L-Citrulline

Systematic review, 2026

The review of citrulline supplementation in postmenopausal women reports vascular measures as the most consistently affected domain, with muscular and metabolic findings less consistent across the included studies.

BMC Women's Health
L-Tyrosine

Randomised trial, 2026

In a crossover trial in 30 healthy men taking 0 to 4 g a day for 4 weeks, no dose-related changes appeared in blood, biochemical or electrolyte laboratory measures, and mild side effects were no more common than with placebo.

Nutrients
Kanna (Sceletium Tortuosum)

Systematic review, 2021

A review of traditional and modern human evidence found only a few short trials of a standardized Sceletium extract, reporting mood and cognitive test changes in healthy adults, with the evidence called limited overall.

Current neuropharmacology
L-Citrulline

Meta-analysis, 2025

Across 21 randomised trials, l-citrulline showed no overall effect on body weight, fat mass or fat-free mass, with reductions in fat mass only in exploratory subgroups over age 40 or above 6 g a day.

Nutrients
Huperzine A (Huperzia serrata leaf standardized extract)

Randomised trial, 1999

In 34 matched pairs of adolescent students reporting poor memory, four weeks of 50 micrograms huperzine A twice daily raised memory quotient to 115 versus 104 on placebo, alongside higher language class scores.

Zhongguo Yao Li Xue Bao
Agmatine Sulfate

Randomised trial, 2010

In an open-label study, agmatine sulfate up to 3.56 g a day kept blood safety measures normal, with mild digestive upset in three participants at the highest dose that cleared.

Pain Medicine
L-Tyrosine

Randomised controlled trial, 1999

Cadets taking 2 g of tyrosine daily through a week of demanding military training scored higher on memory and tracking tasks and showed lower systolic blood pressure than those on a calorie-matched control drink.

Brain Research Bulletin
Betaine Anhydrous

Randomised trial, 2022

In 18 recreationally trained men, 14 days of 6 g a day betaine anhydrous did not change the number of one-leg press repetitions completed, though the post-exercise rise in the marker IGF-1 was greater than with placebo.

Nutrients
Betaine Anhydrous

Meta-analysis, 2021

Across randomized trials, betaine supplementation lowered plasma homocysteine by about 1.3 micromol/L, and at doses under 4 g a day it did so without the rise in total and LDL cholesterol seen at higher doses.

Critical Reviews in Food Science and Nutrition

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

What this formula earned

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

  • Studied in people22 human studies on Creatine Monohydrate back this formula, each one cited.
  • A mechanism that is settledHow L-Citrulline and Creatine Monohydrate work is settled pharmacology.
  • Studied together, not just separatelyL-Citrulline and Creatine Monohydrate have been studied together, not only separately.
  • Recent work on the recordThe most recent study on this record was published in 2024.
  • Serving amount inside the studied rangeEach serving carries 4,500 mg of L-Citrulline, inside the range the published research used.
  • A stated daily maintenance amountL-Citrulline is here at a daily maintenance amount, which is what a daily supplement is for.
  • Why this formatIt is a powder, so the serving scales to the amount you want and mixes into something you already drink.
  • The exact form, describedThe label names its forms exactly: L-Citrulline, Creatine monohydrate, Glycerol powder, high-yield glycerol powder. The record says what each one is and what it suits.
  • Full label disclosureEvery ingredient on this label carries its own declared amount.
  • Where it comes from and how it is madeL-Citrulline is made by fermentation.
  • Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
  • A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
What the trials show

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

  • L-Citrullinewithin about 1 hour of a single doseMeasured within a day

    In a randomised double-blind crossover trial in 19 recreationally active women, a single 8 g dose of citrulline malate taken 60 minutes before testing raised total work in a 5-repetition isokinetic leg extension protocol compared with placebo, with no difference in peak torque and no difference in the 50-repetition protocol. A separate crossover trial in 10 well-trained men using 12 g 60 minutes before high-intensity cycling found no change in time to exhaustion or power.

    Early
  • Creatine Monohydrateabout 4 weeks of daily useBuilds with daily use

    In the trial record, muscle creatine stores rise to a loaded level over about 4 weeks at 3 g daily, or about 1 week with a higher loading dose, and return toward baseline about 4 weeks after stopping.

    Strong
  • Betaine Anhydrousat least 1 week of daily use, measured at 14 days in the trialBuilds with daily use

    In a randomised double-blind crossover trial in 12 resistance-trained men, 14 days of betaine at 1.25 g twice daily raised bench throw power and isometric bench press force compared with placebo, with no change in jump squat power or repetitions completed. A meta-analysis of 17 trials in 317 participants reported a modest pooled effect on maximal strength of 0.47 standardised mean difference for regimens of at least 7 days.

    Promising
  • L-Tyrosineabout two hours after a single dose, under cold stressMeasured within a day

    Two controlled crossover trials in cold-exposure stress measured working memory at a set interval after dosing. Eight men took 150 mg per kg of L-tyrosine two hours before a 30 minute delayed matching-to-sample task at 4 degrees Celsius. Matching accuracy at the longest delay returned to the level seen at 22 degrees Celsius. In 19 volunteers immersed twice for 90 minutes in roughly 10 degree water, a 150 mg per kg bar taken before each immersion raised correct responses on the same memory measure. Both were small trials in an induced-stress setting, and a later crossover trial under exercise heat stress in eight men found no cognitive change despite raised serum tyrosine.

    Early
  • Caffeine Anhydrouswithin about 45 to 60 minutes of a single doseMeasured within a day

    In a double-blind placebo-controlled crossover trial, 15 resistance-trained women took 4 mg per kg body mass of caffeine 60 minutes before a strength and power battery. Squat one-repetition maximum rose 4.5 percent and countermovement jump height 7.6 percent against placebo. A separate crossover trial in 11 active adults began its cycling tests 45 minutes after a 3 mg per kg capsule and recorded a peak-power increase of about 4 percent on the first day of ingestion.

    Norum et al., 2020PMID 32681596
    Lara et al., 2019PMID 30673725
    Promising
  • Caffeine Anhydrousheld for about 15 to 18 days of daily use, then narrowedBuilds with daily use

    One crossover trial mapped the day-to-day time course in 11 healthy active adults taking 3 mg per kg per day for 20 consecutive days. Peak cycling power in the incremental test stayed about 4.0 percent above placebo for the first 15 days and the difference then lessened. Wingate peak power was still raised on days 1, 4, 15 and 18 by about 4.9 percent. The authors describe the shrinking margin as progressive tolerance. This is one trial with 11 participants.

    Lara et al., 2019PMID 30673725
    Early

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

General timing

How each ingredient usually behaves over time.

12 ingredients, from each one's own page.

6 more
  • Agmatine SulfateWithin 30 to 60 minutes

    Taken before training, muscle fullness shows up within 30 to 60 minutes. The mood and nerve-comfort research runs over weeks and sits mostly in animal work.

    Its own page, the plain answer on timing

  • Kanna (Sceletium Tortuosum)About 30 to 60 minutes

    Most people notice something 30 to 60 minutes after a dose, and it eases off over the next few hours. The small trials on mood measures ran four to twelve weeks.

    Its own page, the plain answer on timing

  • Caffeine AnhydrousAbout five minutes

    Fifteen to forty five minutes for most people, peaking around the hour. How long it lasts depends on liver enzyme activity and varies several fold between people.

    Its own page, the plain answer on timing

  • N-Phenethyl Dimethylamine CitrateTwenty to thirty minutes

    For the mood and drive to arrive. It peaks near the hour mark and eases off across one to three hours.

    Its own page, the plain answer on timing

  • Bioperine

    There is nothing to time on its own. Piperine changes how much of its partner compound reaches your blood, so the timeline you watch is that partner's.

    Its own page, the plain answer on timing

  • Huperzine A (Huperzia serrata leaf standardized extract)Thirty to sixty minutes

    For the enzyme effect, and it lingers for hours afterwards. This one works on a same-day clock rather than a weekly build.

    Its own page, the plain answer on timing

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

Chemical form

The same ingredient, carried differently.

What each form is, and where it fits in a formula. Measured findings carry the study that reported them.

  • L-Citrulline

    The non-protein amino acid citrulline in its uncombined free form, not bonded to another acid, mineral, or carrier. Every labelled gram is citrulline itself.

    Fits
    Suits a formula that wants citrulline on its own with no added acid weight, so the panel gram and the citrulline gram are the same number. Folds cleanly into capsules and unflavored or lightly flavored powders.
    Trade-off
    It carries no malic acid, so a brand following a citrulline-malate dosing protocol cannot match gram-for-gram and has to convert. The plain powder can taste faintly bitter in a simple drink mix.

    In a randomized double-blind placebo-controlled crossover trial, 10 healthy men took 6 g/day of free-form L-citrulline for 7 days. Tolerance to severe-intensity cycling and total work completed were higher than placebo, while L-arginine at the same dose was not.

  • Creatine monohydrate

    Creatine crystallised with one water molecule per creatine molecule, roughly 88 percent creatine by mass, weakly soluble in cold water.

    Fits
    Straightforward powder or capsule dosing where cost per gram of delivered creatine and a long shelf record matter.
    Trade-off
    Grittiness and slow dissolution in cold liquid. Some people notice sediment at the bottom of the glass.
  • Malic acidFormulation aid

    The racemic mixture of D- and L-isomers produced by chemical synthesis from maleic or fumaric acid. A white crystalline powder, freely water-soluble and strongly acidic in solution.

    Fits
    Acidulant and flavour applications in powders, effervescent tablets and confectionery where tartness and pH control are the job.
    Trade-off
    Only the L-isomer is a citric acid cycle substrate, so half the mass of the racemate does not enter that pathway.
  • Betaine anhydrous

    Trimethylglycine, the amino acid glycine carrying three methyl groups on its nitrogen, supplied as a dry zwitterion with no bound water and no counter-ion.

    Fits
    Dissolves readily in water and blends into powders and pre-workout formulas at gram-scale doses, and it carries a high betaine content per gram because there is no bound water or acid weighing the compound down.
    Trade-off
    It is strongly hygroscopic, so it pulls in moisture and can clump or cake in humid conditions, which complicates tableting and storage, and it has a sweet-then-bitter taste that flavored products have to mask.

    In a double-blind randomised controlled trial, 23 untrained young women who took 2.5 g/day betaine anhydrous during 8 weeks of resistance training showed a greater reduction in fat mass and body fat percentage than a placebo group.

  • L-Tyrosine

    The unmodified crystalline amino acid, carrying no salt, ester, or acetyl group. The form produced by fermentation and used in most tyrosine research.

    Fits
    A straightforward, well-characterised powder that fills capsules, tablets, and dry-powder blends, and is the form used across most human tyrosine studies.
    Trade-off
    It is only sparingly water-soluble, so it disperses poorly in liquids and effervescent formats and can leave grit or need a large volume of fluid to dissolve.
  • Agmatine sulfate

    The sulfate salt of decarboxylated arginine. A crystalline, water-soluble powder that is far less hygroscopic than the free base.

    Fits
    Capsules and powders where accurate weighing and shelf stability matter, which is nearly all consumer use.
    Trade-off
    Part of the labelled weight is sulfate counter-ion, so the delivered agmatine base is lower than the stated salt weight.
  • 1 more
  • Caffeine anhydrous

    Dry crystalline free base with no water of crystallisation, close to a hundred percent caffeine by weight

    Fits
    Capsules, tablets and pre-workout powders where an exact milligram figure is needed
    Trade-off
    Potency by volume makes it unforgiving to measure by spoon and it dissolves slowly in cold water. The same potency is what makes accurate dosing possible on a scale

Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.

Format

Powder

It is a powder, so the serving scales to the amount you want and mixes into something you already drink.

Best forGram-scale actives: creatine, collagen, protein, electrolytes, beta-alanine.
Recurring supply suggested

Because the effect builds and holds only with continued daily use, a steady recurring supply is the practical way to keep it going.

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Strong evidence, strong doseVerified Oct 2026
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Questions shoppers ask

Is Gorilla Mode independently verified?
Yes. IngredientMD reviewed this formula independently and verified it in Oct 2026. The verdict is earned, not bought: brands can't edit or purchase it.
What's in Gorilla Mode?
Gorilla Mode is built on L-Citrulline, Creatine Monohydrate, GlycerPump, Malic Acid, Betaine Anhydrous, L-Tyrosine, and more. Each ingredient links to its own evidence page on IngredientMD.
Were ingredient interactions checked?
Yes. The combination was screened against 1,576 documented interactions for these actives in IngredientMD's interaction database.
Who is IngredientMD?
IngredientMD is an independent supplement-science platform. We analyze ingredients and formulas against clinical research, and we verify products only when they clear our bar. Labs run the tests. We review the results.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.

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