Thyroid Support.

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

• Studied in people22 human studies on Zinc back this formula, each one cited.
• A mechanism that is settledHow Vitamin B12 and Iodine work is settled pharmacology.
• Studied together, not just separatelyVitamin B12 and Zinc have been studied together, not only separately.
• Recent work on the recordThe most recent study on this record was published in 2026.
• Serving amount inside the studied rangeEach serving carries 150 mcg of Iodine, inside the range the published research used.
• A stated daily maintenance amountIodine is here at a daily maintenance amount, which is what a daily supplement is for.
• Why this formatIt is a capsule, so the amount per serving is fixed and travels without measuring.
• The exact form, describedThe label names its forms exactly: Cyanocobalamin, Potassium iodide, Magnesium oxide. The record says what each one is and what it suits.
• Full label disclosureEvery ingredient on this label carries its own declared amount.
• Where it comes from and how it is madeVitamin B12 is made by fermentation.
• Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
• A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
• Interaction screen on the recordEvery active on this label was screened against the interaction record, and the screen is published with it.

The combinations the trials actually measured.

One pairing in this formula has been studied as a combination in human trials. Each finding below is what a named study measured, cited and dated, never written by the brand.

• Zinc + SeleniumImmune

  In a two-year trial in older adults, zinc taken together with selenium improved the antibody response to influenza vaccination.

  Girodon et al., 1999 (Arch Intern Med)PMID 10218756

  Early

Findings from trials that studied these actives as a combination. Context for how the actives were tested together, not a statement about any individual and not a claim about this product.

The size of the effect, in plain numbers.

Where a trial measured an actual number, we show it next to the claim. It is the average across the trials, never a promise about one person.

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

• Vitamin B12about 16 weeks of daily oral useBuilds with daily use

  A randomised, double-blind, parallel-group dose-finding trial in 120 older people with mild vitamin B12 deficiency, defined as serum B12 of 100 to 300 pmol/L with methylmalonic acid at or above 0.26 umol/L, gave daily oral cyanocobalamin at 2.5, 100, 250, 500 or 1000 ug for 16 weeks. Mean plasma methylmalonic acid fell 16%, 16%, 23%, 33% and 33% across those doses. Daily doses of 647 to 1032 ug accounted for 80% to 90% of the estimated maximum reduction. The window was measured on a blood marker of B12 status, not on a symptom.

  Eussen et al., 2005 (Arch Intern Med)PMID 15911731

  Promising
• Vitamin B12serum levels peak about seven hours after a single tabletMeasured within a day

  An open-label randomised single-dose pharmacokinetic study in 20 healthy men aged 20 to 45, conducted and authored by staff of Emisphere Technologies, the developer of the SNAC carrier under test, measured serum vitamin B12 after one 5 mg cyanocobalamin tablet, with six men on the marketed tablet. Time to peak serum B12 was 6.83 hours for the marketed tablet and 0.5 hours for the carrier coformulation. Absolute bioavailability was 2.16% and 5.09% respectively. One trial, six men per arm. Serum concentration was measured, not any symptom.

  Castelli et al., 2011 (Clin Ther)PMID 21722960

  Early
• Iodinefrom about eight weeks, deepening through twenty-four weeksBuilds with daily use

  In a 24 week randomised double-blind placebo-controlled trial in 112 mildly iodine-deficient New Zealand adults aged 18 to 40, 150 micrograms of iodine a day as potassium iodate lowered thyroglobulin, a blood marker of iodine status, by 12 percent at 8 weeks, 20 percent at 16 weeks and 27 percent at 24 weeks compared with placebo. Median urinary iodine reached 168 micrograms per litre against 79 on placebo. TSH and free T4 stayed within normal range and did not change significantly.

  Ma and colleagues 2016, Journal of Clinical Endocrinology and MetabolismPMID 26891118

  Promising
• Zincover about five days of lozenges started within 24 hours of symptom onsetBuilds with daily use

  Across three randomised placebo-controlled trials pooled as individual patient data (199 adults with naturally acquired colds, 80 to 92 mg of elemental zinc a day as acetate lozenges), 70 percent of the zinc group had recovered by day 5 against 27 percent on placebo, and colds ran 2.73 days shorter against a 7 day average duration. A separate meta-analysis of seven lozenge trials (575 participants, doses above 75 mg a day, zinc acetate or zinc gluconate) measured cold duration 33 percent shorter, with no significant difference between the two salts.

  Hemilä et al., 2017 (Open Forum Infect Dis)PMID 28480298

  Hemilä et al., 2016 (Br J Clin Pharmacol)PMID 27378206

  Hemilä, 2017 (JRSM Open)PMID 28515951

  Strong
• Zincabout two to four weeks of daily intakeBuilds with daily use

  In a controlled feeding study in nine healthy men, six weeks of restricted zinc intake raised DNA strand breaks in peripheral blood cells, and four weeks of repletion at 11 mg a day, with 20 mg of supplemental zinc for the first seven days, reversed the rise. In a separate randomised placebo-controlled trial in 40 Ethiopian women eating a high-phytate diet, 20 mg a day of zinc sulfate for 17 days lowered mean comet tail moment from 39.7 to 30.0 while plasma zinc did not change significantly. Both windows were measured on a DNA damage marker in blood cells, not on a symptom.

  Song and colleagues 2009, American Journal of Clinical NutritionPMID 19515738

  Joray and colleagues 2015, Nutrition ResearchPMID 25491347

  Early
• Seleniumabout ten weeks of daily useBuilds with daily use

  In a 12 week randomised double-blind placebo-controlled trial in 119 healthy UK adults aged 50 to 64, mean plasma selenium rose from 95.7 ng/mL at baseline to steady state by week 10, reaching 118.3, 152.0 and 177.4 ng/mL on 50, 100 and 200 micrograms a day of selenium-enriched yeast. Plasma selenoprotein P rose in every selenium arm. Platelet glutathione peroxidase activity did not change significantly at any dose or form.

  Hurst and colleagues 2010, American Journal of Clinical NutritionPMID 20181815

  Promising

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

How each ingredient usually behaves over time.

12 ingredients, from each one's own page.

• Vitamin B12

  Markers move first. Methylmalonic acid and homocysteine start shifting within a week or two, while anything you would notice takes several weeks of daily use.

  Its own page, the plain answer on timing ↗

• IodineWeeks, not days

  Thyroid hormone turns over slowly, so the change lands on a urinary iodine measure and a thyroid panel before it lands anywhere in your day.

  Its own page, the plain answer on timing ↗

• Magnesium

  A looser stool can turn up the same day at the higher end. Sleep and cramp changes usually settle in across two to four weeks, because it is refilling a body-wide store.

  Its own page, the plain answer on timing ↗

• ZincWithin days

  Blood zinc moves within days. The parts you would notice, skin behaviour and immune resilience, take four to twelve weeks of steady daily intake.

  Its own page, the plain answer on timing ↗

• Selenium

  No felt onset. Plasma selenium and glutathione peroxidase activity rise over three to six weeks of daily intake and then plateau once the enzyme pool is filled.

  Its own page, the plain answer on timing ↗

• CopperWithin days

  The enzymes that need copper get their supply within days. The change shows on a blood panel rather than in how you feel, and any felt difference takes weeks.

  Its own page, the plain answer on timing ↗

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

The same ingredient, carried differently.

What each form is, and where it fits in a formula. Measured findings carry the study that reported them.

• L-Tyrosine

  The unmodified crystalline amino acid, carrying no salt, ester, or acetyl group. The form produced by fermentation and used in most tyrosine research.

  Fits

  A straightforward, well-characterised powder that fills capsules, tablets, and dry-powder blends, and is the form used across most human tyrosine studies.

  Trade-off

  It is only sparingly water-soluble, so it disperses poorly in liquids and effervescent formats and can leave grit or need a large volume of fluid to dissolve.

• Ashwagandha root powder

  Dried, milled root with no extraction step, so the withanolide content is whatever the raw material carried, typically well under one percent.

  Fits

  Fits traditional preparations and powdered drink mixes where the whole botanical rather than a concentrate is the intent.

  Trade-off

  Far more material is needed for the same withanolide load, and lot-to-lot content varies with growing conditions and root age.

• Bladderwrack powder

  The washed, dried and milled whole alga, carrying its full complement of alginate, fucoidan, phlorotannins, minerals and iodine in native proportions.

  Fits

  Traditional whole-plant use, and formulas that want the fibre fraction as well as the iodine.

  Trade-off

  Iodine and heavy metal content track the harvest rather than a specification unless the batch is assayed, so lot-to-lot variability is the main issue.

• Cayenne pepper powder

  The whole dried and milled fruit, carrying capsaicinoids at natural concentration together with carotenoids, ascorbic acid and fibre.

  Fits

  Culinary style dosing and formulas that want the whole spice rather than an isolated fraction, often standardised by Scoville heat units.

  Trade-off

  Capsaicinoid content varies by cultivar, growing season and grind, so heat units are the only meaningful comparison between lots.

Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.

Capsule

It is a capsule, so the amount per serving is fixed and travels without measuring.