Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Corydalis has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Corydalis alkaloids such as tetrahydropalmatine are cleared largely by hepatic CYP enzymes, and piperine inhibits several of those alongside intestinal efflux transport. Combining the two raises systemic alkaloid exposure. That cuts both ways: it can raise the effect and it can raise the chance of sedation or of interaction with prescription medicines cleared by the same route. Anyone on regular medication should regard this as a caution rather than an upgrade.
Corydalis preparations are used traditionally for rest and calm, and the alkaloid fraction is sedating in animal models. Melatonin acts on circadian signalling through its own receptors. There is no shared mechanism, but the subjective effects add up, and the combination should be approached knowing that.
Corydalis rhizome and turmeric both appear in traditional formulas concerned with circulation and physical comfort. The rationale is long-standing formulation practice rather than a demonstrated biochemical interaction. No controlled human work has tested the pair. Read it as convention with a history behind it.
Corydalis and Angelica sinensis appear together across many classical formulas concerned with circulation and comfort. This is one of the more consistent pairings in the traditional literature. Nothing in the modern controlled literature tests the two against either alone, so the grounding is textual and historical.
Licorice is added to the large majority of classical formulas as a harmonising component, and formulas containing Corydalis are no exception. Separately, licorice at sustained intake affects potassium handling and blood pressure through its effect on cortisol metabolism, which is a real consideration independent of Corydalis. The pairing is formulation convention, and the licorice caution stands on its own.
Silymarin components inhibit several CYP isoforms and UGT-mediated glucuronidation. Corydalis alkaloids are cleared by those same routes. Combining them can raise alkaloid exposure in a way that is not obvious from either label. This is worth flagging as an interaction rather than presenting as a benefit.
Nothing specific on file for Corydalis. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.These are the studies our verdict leans on, chosen from the 2 we read for Corydalis. The full linked list is below.
Read this carefully. These are 42 voluntary, unverified reactions reported to the FDA (openFDA). The number mostly reflects how popular Corydalis is, not how risky it is. A report is not proof Corydalis caused anything. It is a signal of what to watch for, nothing more.
Source: openFDA adverse-event reports. Voluntary reporting, not an incidence rate.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.