Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Motherwort has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Valerian acts on GABAergic signalling and motherwort has been used for centuries in nervine formulas. Stacked, the drowsiness is additive, which is the intent in an evening formula and a problem before driving. The pairing is traditional practice with mechanistic support rather than trial evidence for the combination.
Passionflower flavonoids and motherwort alkaloids both appear in traditional formulas aimed at nervous restlessness. The effect on alertness adds up. Anyone combining them should count total sedative load including anything pharmaceutical.
Lemon balm and motherwort appear together in European herbal practice going back centuries, usually where restlessness comes with a fast heartbeat. Both lean calming, so the effect stacks. Confidence sits at promising because the combination itself has not been formally tested.
Magnesium has a small measured effect on blood pressure, and motherwort preparations have shown mild pressure-lowering signals in preclinical work. Combined, any drop in pressure is additive rather than offsetting. This matters most for people already on pressure-lowering medication.
Motherwort alkaloids reduce platelet aggregation in laboratory work, and nattokinase acts on fibrin. Layering the two raises bleeding risk in principle, particularly alongside anticoagulant medication. The signal is preclinical for motherwort, so this is a caution rather than a measured interaction.
High-dose omega-3 lengthens bleeding time modestly, and motherwort alkaloids show antiplatelet behaviour in preclinical assays. The two together are worth flagging before any planned surgery. The size of the combined effect has not been measured in people.
Motherwort aerial parts carry tannins, and tannins form poorly absorbed complexes with non-heme iron. An iron supplement taken with a motherwort infusion delivers less absorbed iron than one taken with water. Spacing by two hours resolves it.
Motherwort is yi mu cao in Chinese practice, where it sits in blood-moving formulas alongside dang gui. Both are avoided in pregnancy in that same tradition. The pairing is documented practice, not a tested combination.
L-theanine shifts alpha wave activity and takes the edge off arousal, and motherwort leans the same direction. Together the calming effect adds. Neither the size nor the timing of the combined effect has been studied.
Melatonin shifts sleep timing and motherwort adds a general calming effect. In an evening product the two are additive on next-morning grogginess for some people. Start with the lower end of each rather than both at full dose.
Nothing specific on file for Motherwort. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.1 source behind our Motherwort verdict: peer-reviewed studies and registered clinical trials. Every one links straight to PubMed, the journal, or ClinicalTrials.gov. Read them yourself.
Evidence surfaced via Semantic Scholar (Allen Institute for AI) and ClinicalTrials.gov. Ranked by study type and citation weight, not cherry-picked.
Read this carefully. These are 27 voluntary, unverified reactions reported to the FDA (openFDA). The number mostly reflects how popular Motherwort is, not how risky it is. A report is not proof Motherwort caused anything. It is a signal of what to watch for, nothing more.
Source: openFDA adverse-event reports. Voluntary reporting, not an incidence rate.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.