Womens Formula.

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

• Studied in people19 human studies on Total Omega 3 Fatty Acids back this formula, each one cited.
• A mechanism that is settledHow Vitamin A (as 50% beta-carotene, retinyl palmitate) and Vitamin C (as ascorbic acid) work is settled pharmacology.
• Studied together, not just separatelyVitamin A (as 50% beta-carotene, retinyl palmitate) and Vitamin K2 (as menaquinone-7) have been studied together, not only separately.
• Recent work on the recordThe most recent study on this record was published in 2026.
• Serving amount inside the studied rangeEach serving carries 400 mcg of Folate (as L-methylfolate calcium salt), inside the range the published research used.
• A stated daily maintenance amountFolate (as L-methylfolate calcium salt) is here at a daily maintenance amount, which is what a daily supplement is for.
• Why this formatIt is a gummy, which is the format people actually keep taking, and adherence decides whether anything else matters.
• The exact form, describedThe label names its forms exactly: Retinyl palmitate, Ascorbic acid, Vitamin D3 dissolved in an edible oil. The record says what each one is and what it suits.
• Full label disclosureEvery ingredient on this label carries its own declared amount.
• Where it comes from and how it is madeVitamin A (as 50% beta-carotene, retinyl palmitate) is made by more than one route.
• Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
• A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
• Interaction screen on the recordEvery active on this label was screened against the interaction record, and the screen is published with it.

The combinations the trials actually measured.

Two pairings in this formula have been studied as combinations in human trials. Each finding below is what a named study measured, cited and dated, never written by the brand.

• Vitamin D3 (as cholecalciferol) + Vitamin K2 (as menaquinone-7)Bone

  In a meta-analysis of eight randomized trials, vitamin K2 taken together with vitamin D raised total bone mineral density and lowered undercarboxylated osteocalcin, a marker of vitamin K status.

  Kuang et al., 2020 (Food & Function)PMID 32219282

  Promising
• Folate (as L-methylfolate calcium salt) + Vitamin B12 (as methylcobalamin) + Vitamin B6 (as pyridoxal 5-phosphate)Heart

  In a 2025 network meta-analysis of 16 randomized trials in healthy adults, folic acid taken together with vitamins B6 and B12 lowered blood homocysteine more than any single supplement, with the 1 mg folic acid plus 7.2 mg B6 plus 20 micrograms B12 arm ranked most effective versus placebo (mean difference -1.03 micromol/L, 95% CI -1.71 to -0.36).

  Liu et al., 2025 (Nutrition Reviews)PMID 39960689

  Promising

Findings from trials that studied these actives as a combination. Context for how the actives were tested together, not a statement about any individual and not a claim about this product.

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

• Vitamin D3 (as cholecalciferol)about 3 months of daily useBuilds with daily use

  In the trial record, blood vitamin D rises for about 3 months of daily vitamin D3 and then holds at a plateau, near 69 nmol/L at 1,000 IU a day, from a starting level near 41 nmol/L.

  Vieth et al., 2001 (Am J Clin Nutr)PMID 11157326

  Early
• Vitamin K2 (as menaquinone-7)about four weeks of daily useBuilds with daily use

  A double-blind randomised dose-finding trial gave 60 postmenopausal women aged 50 to 69 either 0, 50, 100 or 200 micrograms of menaquinone-7 daily for four weeks on a controlled diet. The ratio of carboxylated to undercarboxylated osteocalcin rose dose dependently, with significant differences from the 0 microgram group at 100 and 200 micrograms. A companion 12-week trial in 120 people aged 20 to 69 confirmed the change at 100 micrograms daily. Both studies were run by authors affiliated with the R and D division of J-Oil Mills. An independent 8-week double-blind trial in 55 healthy prepubertal children found the same direction at 45 micrograms daily. What was measured is a blood marker of vitamin K status, not bone density and not a sensation.

  Inaba et al., 2015 (J Nutr Sci Vitaminol (Tokyo))PMID 26875489

  van Summeren et al., 2009 (Br J Nutr)PMID 19450370

  Promising
• Vitamin K2 (as menaquinone-7)three years of daily use, with measurements at one, two and three yearsBuilds with daily use

  A double-blind randomised trial gave 244 healthy postmenopausal women either placebo or 180 micrograms of menaquinone-7 daily for three years, with bone mineral density measured by DXA at baseline and after each year. Menaquinone-7 decreased the age-related decline in bone mineral content and bone mineral density at the lumbar spine and femoral neck, but not at the total hip. The effect is a slowed decline rather than a gain, and the trial ran three years rather than weeks.

  Knapen et al., 2013 (Osteoporos Int)PMID 23525894

  Promising
• Vitamin B6 (as pyridoxal 5-phosphate)about 20 to 40 days to clear after stoppingBuilds with daily use

  An expert consensus on vitamin B6 use, developed by a six-member Delphi panel with a structured evidence-quality assessment, calculated from pharmacokinetic parameters that complete clearance of vitamin B6 from the body takes a washout period of about 20 to 40 days after intake stops.

  Schellack et al., 2025 (Drug Healthc Patient Saf)PMID 40395441

  Early
• Folate (as L-methylfolate calcium salt)a median of about 36 weeks of daily intakeBuilds with daily use

  A systematic review and Bayesian meta-analysis drew on 108 articles from 14,002 screened records and modelled blood folate against folic acid intake using one-compartment pharmacokinetic models. Red blood cell folate rose 1.78 fold from baseline to steady state at 375 to 570 ug folic acid per day, and reaching that steady state took a median of 36 weeks, 95% credible interval 27 to 52 weeks. Serum or plasma folate rose 11.6% for every 100 ug per day of folic acid intake, 95% credible interval 8.4 to 14.9.

  Crider et al., 2019 (Nutrients)PMID 30609688

  Strong
• Folate (as L-methylfolate calcium salt)about 18 days for serum folate to reach its maximumBuilds with daily use

  A kinetic study in six healthy men aged 22 to 31 gave 3.6 umol per day, 1.6 mg, of deuterium-labelled folic acid for four weeks, with folate tracked in serum, erythrocytes and urine by microbiological assay and gas chromatography mass spectrometry. Serum folate reached its maximum concentration in about 18 days, while isotopic labelling of erythrocyte folate kept rising across the whole four weeks. After supplementation stopped, red blood cell folate and urinary folate excretion declined linearly, and serum folate fell with a slow-phase half-life of 18.7 days. One study, six men, no control group.

  von der Porten et al., 1992 (J Nutr)PMID 1588447

  Early

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

How each ingredient usually behaves over time.

12 ingredients, from each one's own page.

• Vitamin A (as 50% beta-carotene, retinyl palmitate)Weeks, not days

  Weeks to months. Liver stores buffer intake, so vitamin A status moves slowly and shows up on a blood panel rather than as a sensation.

  Its own page, the plain answer on timing ↗

• Vitamin C (as ascorbic acid)Within hours

  Plasma levels climb within hours and plateau near the top of the band. Collagen-linked changes in gums and skin show up across weeks, on examination rather than by sensation.

  Its own page, the plain answer on timing ↗

• Vitamin D3 (as cholecalciferol)About six to twelve weeks

  Blood 25-hydroxyvitamin D climbs over six to twelve weeks on a steady daily dose. It is a panel change first, and anything subjective trails behind it.

  Its own page, the plain answer on timing ↗

• Vitamin E (as d-alpha-tocopherol)Within days

  Plasma levels climb within days, though there's no sensation attached. The change reads on a blood panel rather than in how you feel.

  Its own page, the plain answer on timing ↗

• Vitamin K1 (as phylloquinone)

  There is no onset to feel. Carboxylation picks up within days of steady intake, and it reads on functional markers rather than in how your day goes.

  Its own page, the plain answer on timing ↗

• Vitamin K2 (as menaquinone-7)Days, not hours

  Days for absorption, weeks for the marker. Undercarboxylated osteocalcin falls across roughly four to twelve weeks of daily intake, and that is a status marker rather than an outcome.

  Its own page, the plain answer on timing ↗

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

The same ingredient, carried differently.

What each form is, and where it fits in a formula. Measured findings carry the study that reported them.

• Retinyl palmitate

  Preformed vitamin A in which retinol is joined to palmitic acid, a long-chain saturated fatty acid, forming an oil-soluble ester. It is the same ester form in which the body holds its own vitamin A reserves.

  Fits

  Oil-miscible and stable as an ester, so it drops cleanly into softgels, emulsions and oil-based liquid drops, and it is the everyday preformed vitamin A used across multivitamins.

  Trade-off

  As a fat-soluble preformed retinol it is retained rather than readily cleared, so it counts against the tolerable upper intake and adds to any other retinol a formula or daily regimen already carries.

• Ascorbic acid

  The unbuffered acid, pKa around 4.2, fully water soluble and the reference form for most assays and trials.

  Fits

  Anyone matching a research dose or wanting no added mineral load.

  Trade-off

  The acidity can be noticeable in the stomach for some people at larger single doses, and it is hard on tooth enamel in chewable or powder-in-water use.

• Menaquinone-7 (MK-7)

  The long-side-chain menaquinone, usually made by bacterial fermentation of the kind that gives natto its K2. The seven-unit tail keeps it circulating far longer than the short-chain MK-4, which is why microgram doses are the convention.

  Fits

  Formulas that want a once-daily microgram-level K2 with a fermentation-sourced supply chain.

  Trade-off

  Trial outcomes beyond raising K2 status take months to years to read out, and the muscle-recovery use tested recently showed nothing over placebo.

  In a 12-week double-blind randomised controlled trial, 71 healthy young and older adults took menaquinone-7 at 240 micrograms daily or placebo. Circulating MK-7 rose with supplementation, while recovery from a bout of muscle-damaging resistance exercise did not differ from placebo on strength, function, soreness or inflammatory markers.

  Lithgow et al., 2026 (Medicine and Science in Sports and Exercise)PMID 41843412
• Thiamine mononitrate

  The nitrate salt of thiamine, a near-neutral, only slightly water-soluble powder used widely to fortify flour and to build dry tablets and multivitamins.

  Fits

  Its low moisture uptake and neutral, non-acidic character make it stable in dry powders, premixes and compressed tablets with a long shelf life.

  Trade-off

  It dissolves poorly next to the hydrochloride, so it is a weak fit for liquids and fast-dissolving formats, and the nitrate portion contributes nothing nutritionally.

• Myo-inositol

  The most common naturally occurring stereoisomer of inositol, a six-carbon sugar alcohol (cyclohexanehexol). It is the form found in most foods and in the body's own inositol pool, and is supplied as a free white crystalline powder.

  Fits

  It dissolves readily in water with a mild sweet taste, so it suits high-gram powders, stick packs and drink mixes where a large scoop needs to go into solution cleanly. It is also the form the bulk of inositol research has used.

  Trade-off

  Doses are counted in grams rather than milligrams, so it adds noticeable bulk to a capsule line and usually pushes a product toward a powder or several capsules per serving.

• Pyridoxal

  The aldehyde form, one kinase step from the active coenzyme and not requiring the oxidase step.

  Fits

  Occurs in foods and is the circulating transport form after hepatic processing.

  Trade-off

  Rarely offered as a standalone supplement ingredient, so it is mostly relevant to understanding physiology rather than to choosing a product.

4 more

Calcium L-methylfolate

The calcium salt of (6S)-5-methyltetrahydrofolate, the same reduced folate that already circulates in blood, so it joins the folate cycle without passing through dihydrofolate reductase. Only the 6S (L) diastereomer is the biologically usable one. The calcium salt exists because free 5-MTHF oxidises quickly in air and light and needs a crystalline form that can survive being weighed, blended and pressed.

Fits

Fits prenatal and methylation-themed formulas where a brand wants the circulating form named on the panel, and lines aimed at shoppers who ask about MTHFR variants. It arrives as a free-flowing powder on a carrier, since the neat material is too potent to weigh at production scale, and it blends into capsules, tablets and stick packs. Pairs naturally with a blister or a tight HDPE pack with desiccant.

Trade-off

Raw-material cost per microgram runs well above folic acid, and the powder is sensitive to heat, humidity, light and oxygen, which constrains gummies and long ambient shelf lives. Label maths differs too: a microgram of this form is not a microgram of folic acid in dietary folate equivalents, and a panel that ignores the conversion overstates the dose. The human record is mostly folate-status endpoints rather than clinical outcomes.

Double-blind, randomised, parallel-group trial in 172 healthy women aged 18 to 40, comparing an oral contraceptive combined with levomefolate calcium against the same contraceptive plus folic acid over 24 weeks, then 20 weeks of follow-up. Mean concentration-time curves for plasma folate, red blood cell folate and homocysteine were comparable between the two groups. After dosing stopped, median time for red cell folate to fall below 906 nmol per litre was 10 weeks (95 percent CI 8 to 12). The study was designed and authored by Bayer HealthCare staff.

Diefenbach et al., Int J Womens Health 2013: folate status with levomefolate calcium versus folic acidPMID 23610531

Methylcobalamin

Cobalamin carrying a methyl group on the cobalt centre, the same species used directly by methionine synthase.

Fits

Oral tablets, capsules and powders where a preformed methylated cofactor is wanted.

Trade-off

Calcium D-pantothenate

The calcium salt of D-pantothenic acid: two pantothenate anions paired with one calcium ion, isolated as a stable white crystalline powder.

Fits

The powder is dry and free-flowing and stays that way in the bottle, which suits tablets, capsules and multivitamin blends where the raw acid would clump.

Trade-off

Each dose carries a small amount of elemental calcium as its counterion, and it delivers pantothenate as the upstream salt rather than a pantetheine intermediate.

Choline bitartrate

Choline paired with L-(+)-tartaric acid as a crystalline, freely water-soluble salt.

Fits

Capsules, tablets and powders where a plain choline load is wanted and the tartrate acidity is acceptable.

Trade-off

A large share of the tablet weight is the tartrate counter-ion, so the label dose of salt is well above the choline it delivers.

Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.

Gummy

It is a gummy, which is the format people actually keep taking, and adherence decides whether anything else matters.