Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Lygodium has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
Lygodium japonicum spore, known as hai jin sha, appears in Chinese formulas aimed at urinary flow, and dandelion root fills a comparable role in Western herbal practice. The pairing is convention across two traditions rather than a tested combination. Both are traditionally used to increase urine output, though that has not been measured for Lygodium in people.
Marshmallow root polysaccharide is soothing to mucosal surfaces and is a common companion in urinary tract blends. Lygodium contributes the flavonoid and phenolic fraction. This is formulation convention in the category, and neither claim rests on trial data.
Increased urine flow carries sodium and potassium with it. Plant materials used for urinary flow are also typically potassium rich themselves, which cuts the other way. Anyone on a potassium-sparing or potassium-wasting medication should not stack this without medical input.
Sustained increases in urine volume raise renal magnesium loss. Magnesium separately influences the solubility behaviour of calcium oxalate in urine. Both points are established renal physiology, and neither is an outcome claim for Lygodium.
Silymarin is the reference botanical in liver-support formulation and Lygodium herb has been examined in animals for effects on hepatic lipid accumulation. Putting them together stacks two liver-directed inputs. The Lygodium side of that argument rests on rodent data only, which is worth stating outright rather than implying more.
Betaine homocysteine methyltransferase converts homocysteine back to methionine using betaine as the methyl donor. That methionine becomes SAM-e, which supplies the three methylations that build phosphatidylcholine from phosphatidylethanolamine in the liver. It is the same hepatic lipid export pathway choline feeds, entered from a different point.
Artichoke leaf carries cynarin and caffeoylquinic acids and is a long-standing bitter in this category. Lygodium is used similarly in Chinese practice. The combination is category convention. Bitter plant materials of this kind stimulate bile flow, which is a reason for caution where bile flow is already obstructed.
Lygodium herb carries flavonol glycosides built on quercetin and kaempferol backbones alongside phenolic acids. Adding isolated quercetin puts more of the same class through the same intestinal conjugation capacity. That capacity is saturable, so the two compete as much as they add.
Flavonoid phenoxyl radicals are reduced back to the parent flavonoid by ascorbate. This keeps the plant phenolic pool in its reduced state for longer. It is established solution chemistry, and it says nothing on its own about what either compound does in a person.
Phenolic-rich plant infusions form insoluble complexes with non-heme iron in the gut. The result is less iron crossing the enterocyte from that meal. Separating an iron supplement from the herbal preparation by two hours removes the problem.
Nothing specific on file for Lygodium. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.These are the studies our verdict leans on, chosen from the 2 we read for Lygodium. The full linked list is below.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.