Cross-referencing clinical data
A pairing appears on this page only when a trial gave both ingredients together and measured the result. Mono-Ammonium Glycyrrhizinate has none that clears that bar.
Stitching two separate single-ingredient studies into a pairing is the one thing this engine will not do. When a study of the combination itself holds up at source, it lands here with its citation.
No invented synergy. Where actives were studied on their own rather than together, the record shows each on its own evidence, never a combined effect no trial measured.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
20 pairings are live across the library today. Checked 20 July 2026.
No study gave these as a pair, so they are not in the card above. But the reason they belong together is settled biochemistry, not a guess, so it is worth knowing.
This is the single most important interaction for the ingredient and it runs against potassium status. Sustained intake pushes potassium out in the urine, so a formula pairing the two is not a neutral combination and potassium supplementation does not cancel the underlying enzyme inhibition. Anyone taking it at meaningful daily amounts for weeks should have potassium considered rather than assumed. The effect is dose and duration dependent.
Sodium retention and volume expansion raise blood pressure, and a high sodium intake stacks on top of that same mechanism. The two work in the same direction rather than opposing each other. This is the reason regulatory bodies in several countries cap daily glycyrrhizin intake from confectionery and supplements.
Combining the salt with whole licorice root stacks the same active from two sources and the total daily glycyrrhizin is what matters for the electrolyte effect. Formulators sometimes miss this because the label lists two apparently different ingredients. Deglycyrrhizinated licorice is the exception, since the active has been removed from it.
Marshmallow contributes viscous mucilage that coats mucosal surfaces, a physical effect quite separate from anything glycyrrhizin does. The combination is long-standing in herbal practice. No controlled work has tested whether the pair does more than either alone.
Slippery elm bark supplies polysaccharide mucilage with a physical coating action. The pairing is formulation practice with a long history and no trial evidence for the combination specifically. It carries the same electrolyte considerations as glycyrrhizin alone.
Glycyrrhizinate salts are used at low levels as sweeteners and flavour maskers in oral products. Glycine softens the residual bitterness and licorice note. This is sensory formulation and has no bearing on the physiological effects of either ingredient.
Both are used in formulas aimed at elevated liver enzymes and both have antioxidant and membrane-related mechanistic work behind them. The combination is common commercially. Controlled comparisons of the pair against either alone are thin, so read the pairing as convention supported by mechanism rather than as a demonstrated additive effect.
Ascorbate is added to aqueous formulas to protect oxidisable co-ingredients and hold pH in a range where the glycyrrhizinate salt stays dissolved. It is an excipient-level relationship. No physiological interaction between the two has been described.
Nothing specific on file for Mono-Ammonium Glycyrrhizinate. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.