Gold Standard Pre-Workout.

The gap this formula speaks to.

Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.

Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.

Every one of these is a fact the engine could ground.

Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.

• Studied in people22 human studies on Creatine Monohydrate back this formula, each one cited.
• A mechanism that is settledHow Vitamin D3 and Thiamin work is settled pharmacology.
• Studied together, not just separatelyVitamin D3 and Calcium have been studied together, not only separately.
• Recent work on the recordThe most recent study on this record was published in 2026.
• Serving amount inside the studied rangeEach serving carries 20 mg of Niacin, inside the range the published research used.
• A stated daily maintenance amountNiacin is here at a daily maintenance amount, which is what a daily supplement is for.
• Why this formatIt is a powder, so the serving scales to the amount you want and mixes into something you already drink.
• The exact form, describedThe label names its forms exactly: Vitamin D3 in a carrier oil, lanolin-derived, Thiamin hydrochloride, Nicotinic acid. The record says what each one is and what it suits.
• A declared blend totalAstraGin® Proprietary Blend declares its total, 25 mg per serving, with 2 ingredients listed by weight.
• Where it comes from and how it is madeVitamin D3 is made by more than one route.
• Positions this formula already qualifies forThis formula already qualifies for positions beyond the one it is sold into, on the evidence it carries.
• A position nobody is holding yetSome of those positions are ones almost nobody is selling to yet.
• Interaction screen on the recordEvery active on this label was screened against the interaction record, and the screen is published with it.

The combinations the trials actually measured.

One pairing in this formula has been studied as a combination in human trials. Each finding below is what a named study measured, cited and dated, never written by the brand.

• Folate + Vitamin B12 + Vitamin B6Heart

  In a 2025 network meta-analysis of 16 randomized trials in healthy adults, folic acid taken together with vitamins B6 and B12 lowered blood homocysteine more than any single supplement, with the 1 mg folic acid plus 7.2 mg B6 plus 20 micrograms B12 arm ranked most effective versus placebo (mean difference -1.03 micromol/L, 95% CI -1.71 to -0.36).

  Liu et al., 2025 (Nutrition Reviews)PMID 39960689

  Promising

Findings from trials that studied these actives as a combination. Context for how the actives were tested together, not a statement about any individual and not a claim about this product.

What the trials show about timing.

Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.

• Vitamin D3about 3 months of daily useBuilds with daily use

  In the trial record, blood vitamin D rises for about 3 months of daily vitamin D3 and then holds at a plateau, near 69 nmol/L at 1,000 IU a day, from a starting level near 41 nmol/L.

  Vieth et al., 2001 (Am J Clin Nutr)PMID 11157326

  Early
• Thiaminabout 18 to 30 days of restricted intakeBuilds with daily use

  In the controlled depletion study the EFSA reference opinion reviews, restricting thiamin intake to 0.009 to 0.015 mg/MJ for 30 days brought urinary free thiamin excretion from a mean of 0.283 mg/24 h down to undetectable levels by day 18 of the depletion period.

  EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), 2016 (EFSA Journal)PMID 42006014

  Promising
• Thiaminabout 1 week of renewed intakeBuilds with daily use

  In the same depletion and repletion record the EFSA reference opinion reviews, erythrocyte transketolase activity fell progressively to about 75% of baseline during the 30-day depletion period and returned to its baseline value after 1 week of thiamin repletion.

  EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), 2016 (EFSA Journal)PMID 42006014

  Promising
• Vitamin B6about 20 to 40 days to clear after stoppingBuilds with daily use

  An expert consensus on vitamin B6 use, developed by a six-member Delphi panel with a structured evidence-quality assessment, calculated from pharmacokinetic parameters that complete clearance of vitamin B6 from the body takes a washout period of about 20 to 40 days after intake stops.

  Schellack et al., 2025 (Drug Healthc Patient Saf)PMID 40395441

  Early
• Folatea median of about 36 weeks of daily intakeBuilds with daily use

  A systematic review and Bayesian meta-analysis drew on 108 articles from 14,002 screened records and modelled blood folate against folic acid intake using one-compartment pharmacokinetic models. Red blood cell folate rose 1.78 fold from baseline to steady state at 375 to 570 ug folic acid per day, and reaching that steady state took a median of 36 weeks, 95% credible interval 27 to 52 weeks. Serum or plasma folate rose 11.6% for every 100 ug per day of folic acid intake, 95% credible interval 8.4 to 14.9.

  Crider et al., 2019 (Nutrients)PMID 30609688

  Strong
• Folateabout 18 days for serum folate to reach its maximumBuilds with daily use

  A kinetic study in six healthy men aged 22 to 31 gave 3.6 umol per day, 1.6 mg, of deuterium-labelled folic acid for four weeks, with folate tracked in serum, erythrocytes and urine by microbiological assay and gas chromatography mass spectrometry. Serum folate reached its maximum concentration in about 18 days, while isotopic labelling of erythrocyte folate kept rising across the whole four weeks. After supplementation stopped, red blood cell folate and urinary folate excretion declined linearly, and serum folate fell with a slow-phase half-life of 18.7 days. One study, six men, no control group.

  von der Porten et al., 1992 (J Nutr)PMID 1588447

  Early

Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.

How each ingredient usually behaves over time.

12 ingredients, from each one's own page.

• Vitamin D3About six to twelve weeks

  25-hydroxyvitamin D climbs over roughly six to twelve weeks of daily dosing before it plateaus. It's a blood level you watch rather than a feeling.

  Its own page, the plain answer on timing ↗

• Thiamin

  There is no onset to time in the usual sense. Status markers such as erythrocyte transketolase activity move across weeks, and that is where the change is read.

  Its own page, the plain answer on timing ↗

• Niacin

  Nothing to wait for at everyday amounts. Niacin status shows up on blood work rather than as a sensation. The flush from the nicotinic acid form arrives within 30 minutes.

  Its own page, the plain answer on timing ↗

• Vitamin B6

  Nothing quick. Conversion to the active coenzyme happens within hours, but plasma pyridoxal 5-phosphate takes a couple of weeks to settle at a new level.

  Its own page, the plain answer on timing ↗

• FolateAbout four to eight weeks

  Red cell folate climbs over roughly four to eight weeks. It's a blood panel change rather than a sensation.

  Its own page, the plain answer on timing ↗

• Vitamin B12

  Markers move first. Methylmalonic acid and homocysteine start shifting within a week or two, while anything you would notice takes several weeks of daily use.

  Its own page, the plain answer on timing ↗

How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.

The same ingredient, carried differently.

What each form is, and where it fits in a formula. Measured findings carry the study that reported them.

• Cholecalciferol (vitamin D3)

  The animal-sourced form of vitamin D, made in skin under UVB light and produced commercially from lanolin. Fat-soluble, so it travels with dietary fat and is stored in body fat.

  Fits

  Raising and holding vitamin D status, and the form most supplement trials use.

  Trade-off

  Being fat-soluble it accumulates with sustained high dosing, so intakes are set against the tolerable upper level rather than topped up freely.

  In a 12-week double-blind randomised controlled trial in 108 young women in urban Bangalore, most of whom began vitamin D-deficient, daily vitamin D3 at 400, 600 or 800 IU in a fortified wafer raised serum 25-hydroxyvitamin D, parathyroid hormone fell over time, and effects on bone-turnover markers were modest and not dose specific. The 800 IU dose brought 65 percent of participants to sufficiency.

  Peris et al., 2026 (Nutrients)PMID 42124077
• Nicotinic acid

  The free-acid form of vitamin B3, pyridine-3-carboxylic acid. It is the reference form of niacin, a small water-soluble molecule carrying a bare carboxylic acid group on the pyridine ring.

  Fits

  The long-standing reference form for meeting a vitamin B3 requirement.

  Trade-off

  This is the form behind the familiar warm, tingling skin flush that many people notice soon after a larger dose, a recognized property of the free acid that leads some formulators to reach for an amide or ester instead.

• D-pantothenic acid

  The free acid form of vitamin B5, an amide of pantoic acid and beta-alanine, supplied as a viscous hygroscopic oil or a stabilised liquid rather than a dry salt.

  Fits

  The un-neutralised acid carries no mineral counterion, so it suits liquid drops, syrups and formats where a calcium or sodium salt is not wanted.

  Trade-off

  It is hygroscopic and tends to draw water and turn sticky, which makes it awkward to hold as a dry powder without added stabilisers.

• Creatine monohydrate

  Creatine crystallised with one water molecule per creatine molecule, roughly 88 percent creatine by mass, weakly soluble in cold water.

  Fits

  Straightforward powder or capsule dosing where cost per gram of delivered creatine and a long shelf record matter.

  Trade-off

  Grittiness and slow dissolution in cold liquid. Some people notice sediment at the bottom of the glass.

• AstraGinFormulation aid

  Fine off-white to tan powder, water dispersible, carrying triterpene saponins from both roots. The manufacturer standardises to its own internal marker profile rather than a publicly named compound.

  Fits

  Powders, capsules and tablets where the formulator wants a fixed, repeatable material at a low inclusion rate.

  Trade-off

  The composition and marker set are held as proprietary, so an independent laboratory cannot assay a batch against a published specification or compare two lots.

• Beta-alanine

  The free beta amino acid, freely water soluble, supplied as a crystalline powder

  Fits

  Divided daily doses spread through the day, and anyone who wants to control the amount per serving exactly

  Trade-off

  A single larger dose commonly produces transient skin tingling, which is why the total is usually split

3 more

L-Citrulline

The non-protein amino acid citrulline in its uncombined free form, not bonded to another acid, mineral, or carrier. Every labelled gram is citrulline itself.

Fits

Suits a formula that wants citrulline on its own with no added acid weight, so the panel gram and the citrulline gram are the same number. Folds cleanly into capsules and unflavored or lightly flavored powders.

Trade-off

It carries no malic acid, so a brand following a citrulline-malate dosing protocol cannot match gram-for-gram and has to convert. The plain powder can taste faintly bitter in a simple drink mix.

In a randomized double-blind placebo-controlled crossover trial, 10 healthy men took 6 g/day of free-form L-citrulline for 7 days. Tolerance to severe-intensity cycling and total work completed were higher than placebo, while L-arginine at the same dose was not.

Bailey et al., 2015 (J Appl Physiol)

Acetyl-L-carnitine

An acetylated ester of L-carnitine, carrying an added acetyl group on the carnitine backbone. It is usually sold as the hydrochloride salt for handling.

Fits

Delivers both the carnitine backbone and an acetyl group, and is the form most often chosen for cognition and nootropic-support products. The hydrochloride salt handles well in capsules.

Trade-off

Citrus bioflavonoid complex

A mixed extract of peel and pulp carrying hesperidin, naringin, eriocitrin and residual pectin, usually declared as total bioflavonoids by a colorimetric assay.

Fits

Formulas that want the whole flavonoid profile rather than one molecule, often alongside vitamin C.

Trade-off

Total-bioflavonoid assays do not say how much of any single flavonoid is present, so two products with the same number can differ in composition.

Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.

Powder

It is a powder, so the serving scales to the amount you want and mixes into something you already drink.