About 45% of US adults
take in less vitamin A than the estimated average requirement.
Peer-reviewed analysisVitamin C is the lead active here, studied most for iron status. 20 human studies on Vitamin C back this formula, each one cited. Each serving carries 400 mg of Vitamin C, inside the range the published research used. Who it fits: for everyone, adults.
Verified by IngredientMDThe panel on the left is the one we evaluated, line by line.
All 88 actives checked against the clinical evidence: dose, form, and what the research actually shows.
Doses, ratios, and how the ingredients work together. That assessment is the verdict above: "Strong evidence, strong dose".
The verdict is public and identical whether or not a brand pays. A formula that does not clear the bar gets nothing.
Read by the engine against 2.1 million data points from clinical trials, PubMed and more than a hundred vetted sources. No individual reviewer is named or implied.
Cross-checked against 8,931 documented interactions for these actives.
Public health figures the engine matched to this formula's ingredients. Reported by their source, cited and dated, never written by the brand.
About 45% of US adults
take in less vitamin A than the estimated average requirement.
Peer-reviewed analysisAbout 46% of US adults
take in less vitamin C than the estimated average requirement.
Peer-reviewed analysisAbout 41% of US adults
have blood vitamin D below the level considered sufficient.
Peer-reviewed analysisAbout 84% of US adults
take in less vitamin E than the estimated average requirement.
Peer-reviewed analysisFewer than 1 in 10 Americans
take in enough choline to meet the adequate intake.
Peer-reviewed analysisAbout 42% of Americans
take in less calcium than the estimated average requirement.
NHANESAbout 48% of Americans
take in less magnesium than recommended from food and drink.
NIH Office of Dietary SupplementsAbout 15% of US adults
take in less zinc than the estimated average requirement.
Peer-reviewed analysisMore than 1 in 3 US adults
regularly sleep less than the recommended seven hours a night.
Peer-reviewed analysisAbout 24% of US girls aged 14 to 18
take in less copper from food and drink than the estimated average requirement.
NHANESUSDA advises fortified foods or supplements after 50
In its national intake tables USDA notes that "it is advised that individuals over 50 meet their B12 requirement with fortified foods or supplements".
NHANESUS pregnant women, median 129 micrograms per litre
Between 2005 and 2010, US pregnant women had a median urine iodine level of 129 micrograms per liter, below the range considered adequate in pregnancy.
Peer-reviewed analysisMeta-analysis, 2005
Across 30 trials in 4,749 people, niacin raised HDL cholesterol by about 16 percent, lowered triglycerides by about 20 percent, and lowered LDL cholesterol by about 14 percent.
Journal of the American College of CardiologyRandomised trial, 2014
Pantethine, a vitamin B5 derivative, lowered LDL cholesterol by about 11 percent from baseline versus placebo over 16 weeks in adults at low to moderate cardiovascular risk.
Vascular Health and Risk ManagementMeta-analysis, 2024
Across pooled trials, daily spirulina lowered blood pressure in adults, cutting the top number by about 4.4 and the bottom number by about 2.8.
Phytotherapy ResearchMeta-analysis of randomized controlled trials, 2017
Across 19 trials in 797 people, chlorella lowered the top blood pressure number by about 4.5 points and the bottom by about 1.6 points.
Clinical NutritionMeta-analysis, 2024
Pooled trials of mint species tested effects on blood pressure in adults, with each result's certainty rated separately.
BMC Complementary Medicine and TherapiesMeta-analysis, 2016
Zinc acetate lozenges cut cold symptom length by about 2.7 days, versus a roughly seven day average, across three pooled trials.
British Journal of Clinical PharmacologyMeta-analysis, 2025
Pooling five trials, spinach-derived thylakoid supplements lowered reported hunger by 2.415 mm on a rating scale and raised fullness after eating, with the effect scaling with dose.
Nutrition reviewsMeta-analysis, 2025
Combining 55 trials in 3,545 adults with raised liver enzymes, silymarin lowered the liver enzymes ALT and AST.
BMC Complementary Medicine and TherapiesNarrative review, 2025
Reviewing the human literature, the authors find mostly small early studies, with the steadiest signals on oxidative-stress markers and hemoglobin, and call for more rigorous trials.
Journal of Pharmacy and Bioallied SciencesRandomised trial, 2020
In 18 young adults, a barley leaf drink with an afternoon snack lowered the blood sugar rise afterward and at dinner, most when dinner sugar ran high.
NutrientsRandomised trial, 2025
In healthy adults, polyphenols from raspberry leaf tea lowered the post-meal glucose and insulin rise compared with control.
NutrientsMeta-analysis, 2025
In a network meta-analysis of 19 trials with 1,658 participants, biotin-containing preparations were among the supplements linked to greater hair density, though most individual trials were small.
Frontiers in nutritionMeta-analysis, 2016
Pooling 34 trials, magnesium lowered the top blood pressure number by about 2 mmHg.
The paperMeta-analysis, 2014
Across 13 trials, green tea catechins lowered systolic blood pressure by about 2.08 mmHg and diastolic by about 1.71 mmHg compared with control.
European Journal of NutritionAbout 23 percent lower plasma homocysteine at 0.8 mg daily, with 0.2 mg and 0.4 mg reaching roughly 60 and 90 percent of that
Lowers homocysteine, a blood marker tied to heart risk. Measured in adults, standardised to a pretreatment homocysteine of 12 micromol per litre (95% CI 21 to 26 percent).
Meta-analysisClinical trial, 1987
Fifteen adults with elevated blood lipids who ate 40 g of heat-treated alfalfa seeds three times daily for eight weeks saw median total cholesterol fall about 17% and LDL cholesterol about 18%, with values returning to starting levels after they stopped.
The paperMeta-analysis, 2023
Pooling human trials, Lycium barbarum supplementation was associated with modest reductions in total cholesterol and triglycerides in adults, with variation across studies.
MedicineMeta-analysis, 2023
Pooling randomised trials of anthocyanins, the pigment class that acai is rich in, found modest reductions in total and LDL cholesterol.
Frontiers in nutritionMeta-analysis, 2025
A dose-response pooling of randomised trials found pomegranate supplementation improved several cardiometabolic measures, including blood pressure and blood lipids.
Nutrition, Metabolism, and Cardiovascular DiseasesSystematic review, 2026
A systematic review catalogued gastrointestinal symptoms reported across sodium bicarbonate dosing protocols and described how symptom burden varies with dose, timing and whether the dose is split or given with food.
European Journal of Sport ScienceSystematic review, 2024
Across the reviewed human studies, higher dietary carotenoid intake tracked with more favourable cardiovascular risk markers, an association rather than a demonstrated cause.
NutrientsRandomised trial, 2025
Broccoli supplementation combined with exercise was tested against exercise alone on metabolic and lipoprotein blood markers in adults.
NutrientsMeta-analysis, 2019
Across combined trials, strawberries improved several heart-related blood markers in adults, including lower LDL cholesterol and a blood marker of inflammation.
Food & functionMeta-analysis, 2015
Across 12 trials, vitamin E lowered a blood marker of inflammation by about 0.62 mg/l compared with not taking it.
European Journal of Clinical NutritionRandomised trial, 2016
In resistance-trained adults, a multi-ingredient supplement containing banaba leaf extract raised resting metabolic rate acutely, with hemodynamic measures reported as unchanged and the blend meaning the effect is not attributable to banaba alone.
Journal of the International Society of Sports NutritionRandomised trial, 2011
Encapsulated fruit and vegetable concentrates containing acerola were tested for effects on blood vessel dilation in adults with several metabolic risk markers.
Nutrition journalMetabolic balance study (crossover), 2006
In 43 healthy young women eating normal diets, over 90 percent of dietary molybdenum was absorbed and mostly excreted in urine, staying balanced across intakes of about 150 to 318 micrograms a day.
Journal of Trace Elements in Medicine and BiologyMeta-analysis, 2014
Across 25 trials in adults with high blood sugar, chromium lowered HbA1c, a marker of average blood sugar, by about 0.55 percentage points and fasting glucose by about 1.15.
Journal of Clinical Pharmacy and TherapeuticsSystematic review, 2025
Pooling human trials of apple cider vinegar, the review found small reductions in body weight and waist measures in adults with raised blood sugar or excess body weight, and described the evidence base as limited.
NutrientsSystematic review, 2024
A systematic review of nutraceuticals in adults with elevated blood sugar lists banaba leaf and its corosolic acid among the plant extracts with reported effects on glucose handling, at modest evidence quality.
NutrientsMeta-analysis, 2012
In trials directly comparing the two forms, vitamin D3 raised blood 25-hydroxyvitamin D more than vitamin D2 did (P = 0.001).
American Journal of Clinical NutritionRandomised trial, 2024
A daily freeze-dried kale bar improved several blood sugar and metabolic markers in adults with high blood sugar compared with placebo.
NutrientsMeta-analysis, 2022
Pooling 16 randomized trials in 6,425 postmenopausal women, vitamin K2 supplementation improved lumbar spine bone mineral density and lowered undercarboxylated osteocalcin.
Frontiers in Public HealthMeta-analysis, 2018
Pooling trials, selenium raised the share of motile sperm by about 3.3 percentage points, with a smaller rise in normally shaped sperm and a higher sperm concentration.
Advances in NutritionMeta-analysis, 2024
Pooled trials found dietary nitrate supplementation improved high intensity cycling sprint performance in recreationally active people by a small margin.
NutrientsMeta-analysis, 2025
Across trials, blueberries produced small improvements in memory and executive function measures.
BiogerontologyMeta-analysis, 2025
Pooled trials of Zataria multiflora, a thyme-family plant rather than thyme itself, reported higher lung function measures and lower oxidative stress markers in adults.
BMC complementary medicine and therapiesClinical trial, 2009
In a pilot study of 17 volunteers, a fresh dandelion leaf extract increased urination frequency in the 5 hours after the first dose and raised the urine output to fluid intake ratio after the second dose, with no change after the third.
Journal of Alternative and Complementary MedicineMeta-analysis, 2024
In a dose-response meta-analysis of randomised trials, riboflavin was associated with about 1.3 fewer severe recurring headache attacks per month compared with control.
Neurological SciencesSystematic review, 2023
Across 18 studies, pyridoxine on its own and in combinations improved nausea scores in pregnancy on both the Rhode and PUQE scales, a use with a long clinical track record.
Archives of Gynecology and ObstetricsMeta-analysis, 2020
Ginger eased nausea severity during pregnancy versus placebo (standardized mean difference 0.82), pooling 13 trials in 1,174 women, with no clear effect on vomiting.
J Matern Fetal Neonatal MedRandomised trial, 2026
Thiamin supplementation improved the thiamin pyrophosphate effect, a blood marker of thiamin adequacy, in children whose levels were low.
Scientific reportsMeta-analysis, 2025
In children of pregnancies with heavy alcohol exposure, choline in pregnancy was linked to higher memory scores (moderate confidence), and after birth to better overall thinking (lower confidence).
Pediatrics and NeonatologySystematic review and meta-analysis, 2020
In pregnant women with mild to moderate iodine deficiency, iodine lowered a thyroid marker and curbed the usual pregnancy rise in thyroid size. Infant cognitive, language and motor scores showed no change across trials.
American Journal of Clinical NutritionSystematic review and meta-analysis of observational studies, 2025
Pooling observational studies, higher dietary copper intake was associated with slightly higher lumbar spine bone mineral density (mean difference 0.02 g/cm2), while the hip difference was not statistically significant.
Calcified Tissue InternationalPopulation figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Each line below was derived from this formula's own record at the time of verification. Nothing here was written by the brand, and nothing can be added that the evidence does not carry.
Five pairings in this formula have been studied as combinations in human trials. Each finding below is what a named study measured, cited and dated, never written by the brand.
In the AREDS2 trial long-term follow-up, lutein and zeaxanthin taken together were associated with a modestly lower risk of progression to late age-related macular degeneration, while the trial original primary analysis was not significant.
In a two-year trial in older adults, zinc taken together with selenium improved the antibody response to influenza vaccination.
In a 12-month randomised, double-blind trial, 98 adults aged 50 and over drank a litre a day of either a naturally calcium- and magnesium-rich mineral water or a low-mineral water. The mineral-rich group had fewer falls at the 6-month assessment and higher appendicular muscle mass, with the minerals delivered as drinking water rather than a capsule.
In a 2025 network meta-analysis of 16 randomized trials in healthy adults, folic acid taken together with vitamins B6 and B12 lowered blood homocysteine more than any single supplement, with the 1 mg folic acid plus 7.2 mg B6 plus 20 micrograms B12 arm ranked most effective versus placebo (mean difference -1.03 micromol/L, 95% CI -1.71 to -0.36).
In an 8-week randomized trial of 264 stressed healthy adults with low magnesium, magnesium plus vitamin B6 and magnesium alone reduced perceived stress about equally overall. In the prespecified subgroup that started with severe stress, the combination improved stress scores 24% more than magnesium alone.
Research strength. Research strength says how much work stands behind the combination. It is never a product score.
Fail closed. Where actives were studied on their own rather than together, each shows on its own evidence, never a combined effect no trial measured.
Independent record. Every finding is cited to a named trial, dated, and never written by the brand.
Findings from trials that studied these actives as a combination. Context for how the actives were tested together, not a statement about any individual and not a claim about this product.
Where a trial measured an actual number, we show it next to the claim. It is the average across the trials, never a promise about one person.
About 52 percent lower risk of developing a cold, in trials of people undergoing brief periods of severe physical exertion.
Read at the source. The magnitude sits beside the same trial the claim already cites. It describes what the trials measured, never what any one person will feel.
Time-to-effect windows the engine read from the trial record. Each is a window a named study measured, cited and dated, never written by the brand.
In a randomised crossover trial, 12 healthy adults consumed 101.7 mg of vitamin C as a powder, as raw fruits and vegetables, or as juice, and plasma vitamin C rose after every intake form, with plasma and urinary levels tracked over the 24 hours following the single dose.
In the trial record, blood vitamin D rises for about 3 months of daily vitamin D3 and then holds at a plateau, near 69 nmol/L at 1,000 IU a day, from a starting level near 41 nmol/L.
In a 3-phase crossover using two deuterium-labelled forms of alpha-tocopherol, healthy women absorbed about 55 percent of an oral dose taken with a 40 percent fat meal and about 64 percent with a fat-free meal, with samples tracked over 72 hours. The authors conclude absorption is not limited by absent fat or fasting, and that vitamin E leaves the intestine by a prolonged process.
A double-blind randomised dose-finding trial gave 60 postmenopausal women aged 50 to 69 either 0, 50, 100 or 200 micrograms of menaquinone-7 daily for four weeks on a controlled diet. The ratio of carboxylated to undercarboxylated osteocalcin rose dose dependently, with significant differences from the 0 microgram group at 100 and 200 micrograms. A companion 12-week trial in 120 people aged 20 to 69 confirmed the change at 100 micrograms daily. Both studies were run by authors affiliated with the R and D division of J-Oil Mills. An independent 8-week double-blind trial in 55 healthy prepubertal children found the same direction at 45 micrograms daily. What was measured is a blood marker of vitamin K status, not bone density and not a sensation.
A double-blind randomised trial gave 244 healthy postmenopausal women either placebo or 180 micrograms of menaquinone-7 daily for three years, with bone mineral density measured by DXA at baseline and after each year. Menaquinone-7 decreased the age-related decline in bone mineral content and bone mineral density at the lumbar spine and femoral neck, but not at the total hip. The effect is a slowed decline rather than a gain, and the trial ran three years rather than weeks.
In the controlled depletion study the EFSA reference opinion reviews, restricting thiamin intake to 0.009 to 0.015 mg/MJ for 30 days brought urinary free thiamin excretion from a mean of 0.283 mg/24 h down to undetectable levels by day 18 of the depletion period.
In the same depletion and repletion record the EFSA reference opinion reviews, erythrocyte transketolase activity fell progressively to about 75% of baseline during the 30-day depletion period and returned to its baseline value after 1 week of thiamin repletion.
In an intervention the EFSA reference opinion reviews, adults whose baseline riboflavin intake and status were unknown received 5 mg/day of riboflavin for 8 weeks, and haemoglobin concentration, haematocrit and erythrocyte count all rose significantly over that period.
An expert consensus on vitamin B6 use, developed by a six-member Delphi panel with a structured evidence-quality assessment, calculated from pharmacokinetic parameters that complete clearance of vitamin B6 from the body takes a washout period of about 20 to 40 days after intake stops.
A systematic review and Bayesian meta-analysis drew on 108 articles from 14,002 screened records and modelled blood folate against folic acid intake using one-compartment pharmacokinetic models. Red blood cell folate rose 1.78 fold from baseline to steady state at 375 to 570 ug folic acid per day, and reaching that steady state took a median of 36 weeks, 95% credible interval 27 to 52 weeks. Serum or plasma folate rose 11.6% for every 100 ug per day of folic acid intake, 95% credible interval 8.4 to 14.9.
A kinetic study in six healthy men aged 22 to 31 gave 3.6 umol per day, 1.6 mg, of deuterium-labelled folic acid for four weeks, with folate tracked in serum, erythrocytes and urine by microbiological assay and gas chromatography mass spectrometry. Serum folate reached its maximum concentration in about 18 days, while isotopic labelling of erythrocyte folate kept rising across the whole four weeks. After supplementation stopped, red blood cell folate and urinary folate excretion declined linearly, and serum folate fell with a slow-phase half-life of 18.7 days. One study, six men, no control group.
A randomised, double-blind, parallel-group dose-finding trial in 120 older people with mild vitamin B12 deficiency, defined as serum B12 of 100 to 300 pmol/L with methylmalonic acid at or above 0.26 umol/L, gave daily oral cyanocobalamin at 2.5, 100, 250, 500 or 1000 ug for 16 weeks. Mean plasma methylmalonic acid fell 16%, 16%, 23%, 33% and 33% across those doses. Daily doses of 647 to 1032 ug accounted for 80% to 90% of the estimated maximum reduction. The window was measured on a blood marker of B12 status, not on a symptom.
An open-label randomised single-dose pharmacokinetic study in 20 healthy men aged 20 to 45, conducted and authored by staff of Emisphere Technologies, the developer of the SNAC carrier under test, measured serum vitamin B12 after one 5 mg cyanocobalamin tablet, with six men on the marketed tablet. Time to peak serum B12 was 6.83 hours for the marketed tablet and 0.5 hours for the carrier coformulation. Absolute bioavailability was 2.16% and 5.09% respectively. One trial, six men per arm. Serum concentration was measured, not any symptom.
In an open trial with no placebo arm, 71 patients with brittle or splitting fingernails took 2.5 mg of biotin a day. Of the 45 cases that could be evaluated, 41 were rated as having firmer and harder nails after an average of 5.5 months of treatment, standard deviation 2.3 months. The rating was clinical judgement rather than an instrument reading, and there was no control group, so the window describes when the raters recorded change, not a placebo adjusted effect.
In a controlled feeding study, lactating women randomised to 480 or 930 mg choline per day for 10 to 12 weeks showed that the higher intake increased breast milk choline content by raising output of endogenously synthesised choline metabolites.
A randomised cross-over trial in ten women of mean age 69 gave a single 500 mg dose of calcium as citrate fasting, citrate with a meal, fortified juice or a dairy product meal, with blood drawn before and at 1, 2, 4 and 6 hours. Serum ionised and total calcium increased significantly from baseline over six hours, with the rise similar after fortified juice, delayed when citrate was taken with a meal and smaller after the dairy meal. A separate double-blind cross-over trial in 25 postmenopausal women measured parathyroid hormone and a bone resorption marker 12 hours after a single calcium dose. Ten participants is a small sample, and what moved was blood chemistry, not a sensation.
A systematic review of ten randomised crossover trials in 225 healthy adults aged 18 to 64 examined inorganic phosphorus supplementation taken with meals against postprandial metabolic outcomes. Three of the four studies measuring diet-induced thermogenesis reported a significant positive association with phosphorus in the hours after eating. The reviewers temper the finding: few studies, modest samples, methodological heterogeneity, and association rather than established cause.
In a 24 week randomised double-blind placebo-controlled trial in 112 mildly iodine-deficient New Zealand adults aged 18 to 40, 150 micrograms of iodine a day as potassium iodate lowered thyroglobulin, a blood marker of iodine status, by 12 percent at 8 weeks, 20 percent at 16 weeks and 27 percent at 24 weeks compared with placebo. Median urinary iodine reached 168 micrograms per litre against 79 on placebo. TSH and free T4 stayed within normal range and did not change significantly.
Across three randomised placebo-controlled trials pooled as individual patient data (199 adults with naturally acquired colds, 80 to 92 mg of elemental zinc a day as acetate lozenges), 70 percent of the zinc group had recovered by day 5 against 27 percent on placebo, and colds ran 2.73 days shorter against a 7 day average duration. A separate meta-analysis of seven lozenge trials (575 participants, doses above 75 mg a day, zinc acetate or zinc gluconate) measured cold duration 33 percent shorter, with no significant difference between the two salts.
In a controlled feeding study in nine healthy men, six weeks of restricted zinc intake raised DNA strand breaks in peripheral blood cells, and four weeks of repletion at 11 mg a day, with 20 mg of supplemental zinc for the first seven days, reversed the rise. In a separate randomised placebo-controlled trial in 40 Ethiopian women eating a high-phytate diet, 20 mg a day of zinc sulfate for 17 days lowered mean comet tail moment from 39.7 to 30.0 while plasma zinc did not change significantly. Both windows were measured on a DNA damage marker in blood cells, not on a symptom.
In a 12 week randomised double-blind placebo-controlled trial in 119 healthy UK adults aged 50 to 64, mean plasma selenium rose from 95.7 ng/mL at baseline to steady state by week 10, reaching 118.3, 152.0 and 177.4 ng/mL on 50, 100 and 200 micrograms a day of selenium-enriched yeast. Plasma selenoprotein P rose in every selenium arm. Platelet glutathione peroxidase activity did not change significantly at any dose or form.
In an 8 week pilot with a parallel placebo group, 8 young women taking 2 mg of copper a day as copper glycinate showed a 9 percent mean rise in serum ceruloplasmin and a 75 percent rise in diamine oxidase, alongside a 39 percent fall in plasma F2-alpha isoprostanes. Erythrocyte copper-zinc superoxide dismutase did not change. In a separate 4 week double-blind crossover in 20 men with moderately high cholesterol at the same 2 mg a day, copper moved no measure across the whole group and raised superoxide dismutase and diamine oxidase only in the 10 men who started below the median. Both are small and both measured enzymes in blood, not a symptom.
In the excretion studies the EFSA reference opinion reviews, urinary output closely tracked dietary sodium once intake was held steady: 98% of dietary sodium appeared in 24-hour urine in a 3-day study, and 86% of sodium ingested over 4 weeks was recovered in 24-hour urine collected during the same period.
Windows measured in the cited trials. Context for how the active behaves over time, not a statement about any individual and not a claim about this product.
12 ingredients, from each one's own page.
Weeks to months. Liver stores buffer intake, so vitamin A status moves slowly and shows up on a blood panel rather than as a sensation.
Blood levels rise within hours and tissue pools fill over days. Collagen-linked changes in skin and gums build over weeks and show as tissue quality, not as a sensation.
25-hydroxyvitamin D climbs over roughly six to twelve weeks of daily dosing before it plateaus. It's a blood level you watch rather than a feeling.
Plasma alpha-tocopherol climbs within days of daily intake, and anything you'd notice in skin condition is a slow change across a couple of months.
Clotting factor carboxylation responds within days. The bone marker undercarboxylated osteocalcin shifts across roughly four to twelve weeks, so this shows up on a panel.
There is no onset to time in the usual sense. Status markers such as erythrocyte transketolase activity move across weeks, and that is where the change is read.
Urine turns bright yellow within hours of the first dose. Status itself, read as red cell glutathione reductase activity, shifts across two to eight weeks.
Nothing to wait for at everyday amounts. Niacin status shows up on blood work rather than as a sensation. The flush from the nicotinic acid form arrives within 30 minutes.
Nothing quick. Conversion to the active coenzyme happens within hours, but plasma pyridoxal 5-phosphate takes a couple of weeks to settle at a new level.
Red cell folate climbs over roughly four to eight weeks. It's a blood panel change rather than a sensation.
Markers move first. Methylmalonic acid and homocysteine start shifting within a week or two, while anything you would notice takes several weeks of daily use.
Fingernails grow around 3mm a month, so it takes roughly 8 to 12 weeks before enough new plate has grown out to judge the difference by eye.
How each ingredient usually behaves over time, from its own page on IngredientMD. General timing for the ingredient, not a measurement of this product.
What each form is, and where it fits in a formula. Measured findings carry the study that reported them.
The animal-sourced form of vitamin D, made in skin under UVB light and produced commercially from lanolin. Fat-soluble, so it travels with dietary fat and is stored in body fat.
In a 12-week double-blind randomised controlled trial in 108 young women in urban Bangalore, most of whom began vitamin D-deficient, daily vitamin D3 at 400, 600 or 800 IU in a fortified wafer raised serum 25-hydroxyvitamin D, parathyroid hormone fell over time, and effects on bone-turnover markers were modest and not dose specific. The 800 IU dose brought 65 percent of participants to sufficiency.
The free vitamin B2 molecule, an isoalloxazine ring joined to a ribitol sugar chain, supplied as the unmodified crystalline compound with no added salt or phosphate group.
The free-acid form of vitamin B3, pyridine-3-carboxylic acid. It is the reference form of niacin, a small water-soluble molecule carrying a bare carboxylic acid group on the pyridine ring.
The free acid form of vitamin B5, an amide of pantoic acid and beta-alanine, supplied as a viscous hygroscopic oil or a stabilised liquid rather than a dry salt.
Unfractionated root material carrying the full constituent profile including undeclared glycyrrhizin
An extract of the root alone, standardised to its withanolide content, the constituent family the clinical literature doses by. Root-only sourcing distinguishes it from root-plus-leaf extracts.
A systematic review of 23 randomised trials in 2,317 generally healthy adults taking standardised ashwagandha root extract at 125 to 600 mg per day, from a single dose to 180 days, found hepatic, renal, haematological, endocrine and cardiovascular biomarkers stayed within normal clinical ranges, reductions in cortisol were consistently observed, testosterone shifts stayed within physiological range, and no serious adverse events were attributed to the extract.
A 50:50 mixture of the R and S enantiomers of lipoic acid, sold as the free acid. The same molecule is also labelled thioctic acid.
In an open-label four-way crossover in 24 adults, a racemic solution produced higher peak plasma concentrations of both enantiomers than the 200, 300, and 600 mg tablet forms.
The oxidised, quinone form of coenzyme Q10: a fat soluble benzoquinone ring carrying a ten unit isoprenoid tail, supplied as a yellow orange crystalline powder made by yeast fermentation. It is the redox form nearly all CoQ10 raw material ships as, and the form used across the long running clinical trial record.
The free stilbene aglycone in its trans geometric configuration, a single molecule of formula C14H12O3 (three hydroxyls on a two-ring stilbene skeleton), sold either purified from plant material or made synthetically.
During concentration, EPA and DHA are cleaved from glycerol and each bound individually to ethanol, so every fatty acid rides on its own ethyl group rather than a shared glycerol backbone. This arrangement allows a high EPA and DHA percentage.
In a six-month double-blind RCT in 150 adults, the rise in the omega-3 index (EPA and DHA in red blood cell membranes) with the ethyl ester form was smaller than with an equal dose of re-esterified triglyceride. A two-week trial found lower serum appearance versus natural fish oil.
Descriptions of the form itself, read from the cited studies. Not a comparison between products and not a statement about any individual.
It is a powder, so the serving scales to the amount you want and mixes into something you already drink.
Put an earned verification on your own product page.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This record is not medical advice. Always consult your healthcare provider before starting any supplement regimen.