Gentle chelated copper. Iron and collagen support. Supplies copper bound to glycine. Copper is what iron loading, collagen cross-linking and superoxide dismutase all need, so it works quietly as an enzyme cofactor.
Reviewed March 2026
Public health figures for this ingredient, reported by the agencies that publish them, cited and dated.
About 24% of US girls aged 14 to 18
take in less copper from food and drink than the estimated average requirement.
USDA ARS, Usual Nutrient Intake from Food and Beverages, by Gender and Age, WWEIA NHANES 2013-2016, Table A 39 (copper), females 14-18: 24% below EAR (SE 2.6). ↗About 14% of US women aged 71 and over
take in less copper from food and drink than the estimated average requirement.
USDA ARS, Usual Nutrient Intake from Food and Beverages, by Gender and Age, WWEIA NHANES 2013-2016, Table A 39 (copper), females 71+: 14% below EAR (SE 1.8). ↗About 11% of US women aged 19 and over
take in less copper from food and drink than the estimated average requirement.
USDA ARS, Usual Nutrient Intake from Food and Beverages, by Gender and Age, WWEIA NHANES 2013-2016, Table A 39 (copper), females 19+: 11% below EAR (SE 0.7). ↗Population figures from public health data. Context for the category, not a statement about any individual and not a claim about this product.
Source: NIH ODS + Klevay 2000 review
These words describe the research, not the molecule's worth. Research strength is how much work stands behind one claim, and it is never a product score.
Based on 15 human trials.
Why these belong in the same formula. Each row says what the basis is, from settled biochemistry through to a trial that measured the pair.
Sustained high zinc intake induces metallothionein in the gut lining, which binds copper and holds it in shed intestinal cells, lowering how much copper is absorbed. Pairing a modest amount of copper with zinc offsets this competition and helps maintain normal copper status.
Copper is the cofactor for ceruloplasmin, the ferroxidase that oxidizes iron so it can load onto transferrin and move through the blood. Adequate copper therefore supports the normal transport and use of the iron the body already has.
Large doses of ascorbic acid reduce copper from its cupric to cuprous state and can blunt copper absorption and ceruloplasmin oxidase activity. Spacing high-dose vitamin C apart from copper helps keep copper uptake in the normal range.
Molybdate and sulfide form thiomolybdates in the gut that bind copper tightly and carry it out unabsorbed. High molybdenum intake lowers copper status by this route.
Manganese and free copper ions compete at DMT1 on the brush border, so large doses taken together are separated in practice.
Zinc raises enterocyte metallothionein, which binds copper more tightly than zinc and retains it in the cell that is later shed. The effect holds across zinc forms and is the reason copper is paired into long-term zinc formulas.
Tyrosine feeds dopamine synthesis, and the copper enzyme dopamine beta-hydroxylase performs the next conversion to noradrenaline. Copper is the cofactor immediately downstream of the amino acid.
Copper-zinc superoxide dismutase produces hydrogen peroxide from superoxide, and selenium-dependent glutathione peroxidase reduces that peroxide to water. Consecutive steps of one chain need both minerals.
CoQ10 carries electrons to complex III, which hands them to cytochrome c oxidase, whose CuA and CuB centres are copper. Both are needed for electron flow to reach oxygen.
The copper enzyme lysyl oxidase cross-links lysine residues in collagen and elastin. Collagen peptides supply substrate amino acids while copper enables the cross-link that gives the fibre its tensile character.
Silicon is associated with glycosaminoglycan and collagen matrix assembly, and copper drives cross-linking of those same fibres. Different steps of one connective-tissue process.
Quercetin chelates copper through its catechol and 3-hydroxy-4-keto groups, forming poorly absorbed complexes. A large polyphenol dose in the same serving lowers copper uptake.
Catechin galloyl esters bind divalent metals in the lumen and precipitate them. Concentrated extract taken with a copper dose lowers absorption of both.
Phytate binds copper along with zinc and iron in plant-matrix meals. Phytase hydrolyses the inositol phosphate and frees the mineral, which matters most for the dietary copper eaten alongside the chelate.
Psyllium gel traps divalent cations and shortens their contact with absorptive surface. Mineral doses are taken apart from a bulk fibre serving.
Nothing specific on file for Copper Bisglycinate. Match the label to the daily amount above, and tell your doctor what you take.
Not medical advice. Show the label to your pharmacist.The whole-food sources on file. A supplement closes the gap, it does not replace dinner.
A gram-for-gram figure (how much of each you would eat to match a dose) will appear here once it is sourced and reviewed. This page will not print a number it cannot cite.
Copper Bisglycinate is the bisglycinate form of Copper. Same mineral, bound to a different partner, so absorption and feel differ from form to form.
These are the studies our verdict leans on, chosen from the 1,629 we read for Copper Bisglycinate. The full linked list is below.
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.